Apoptosis or programmed cell death is increasingly considered to be a major factor in the development and progression of cardiovascular disease. In patients with heart failure the activation of apoptosis may result in the loss of irreplaceable cardiac myocytes promoting the clinical course of the syndrome. Moreover, in the coronary arteries inflammation and apoptosis may weaken critical structures of the vessel wall leading to plaque rupture and, subsequently, to myocardial infarction. Given these deleterious consequences, it seems almost paradoxical that programmed cell death is an active process that, if initiated under physiological circumstances, is essential for both coordinated tissue growth or destruction of malignant cells. Apoptosis in Cardiac Biology, written by a team of internationally renowned researchers, gives a timely synopsis of basic mechanisms, cellular and structural targets and, finally, clinical implications of programmed cell death in the heart. The expert authors of this volume give concise overviews on general and cell-specific aspects of programmed cell death in cardiac myocytes and fibroblasts, as well as in vascular smooth muscle and endothelial cells. Furthermore, novel therapeutic options arising from the outstanding pathophysiological significance of cardiac apoptosis are presented. This comprehensive review of Apoptosis in Cardiac Biology will be of interest to both clinicians and basic researchers who are active in the fields of cardiology and atherosclerosis.
In November 1889, two young female journalists, Nellie Bly and Elizabeth Bisland, set out for the journey of a lifetime—both with the goal to try to travel around the world in less than 80 days. Read about this amazing round the world journey of these two women, Nellie Bly and Elizabeth Bisland, and learn more about Victoria era travel.
This daily column at GNN.org features all the good news, anniversaries and notable birthdays from this day in history—January 25.
In November 1889, two young female journalists, Nellie Bly and Elizabeth Bisland, set out for the journey of a lifetime—both with the goal to try to travel around the world in less than 80 days. Read about this amazing round the world journey of these two women, Nellie Bly and Elizabeth Bisland, and learn more about Victoria era travel.
Two Victorian women race against each other around the world, in the process countering the cultural inertia of their era.
Journalist Nellie Bly became famous in the late 1800s for her investigative and adventurous stories published primarily in New York World newspaper. Early in her career Bly went undercover to get t…
It's 125 years since intrepid young American journalist Nellie Bly, was the first person to go around the world in 72 days! She beat Jules Verne's 80 day limit.
\"Join two daredevil journalists, Nellie Bly and Elizabeth Bisland, as they race against each other--and the ticking clock--to circle the globe in fewer than 80 days. And by any means possible--ship, train, even foot! Bly, energetic and scrappy, and Bisland, poetic and sophisticated, shared one common goal: to prove that women could not only travel the world but were just as curious, capable, and courageous as any man. Did it really matter who won the race?\"--Jacket flap.\nIncluded in Smithsonian Magazine's Ten Best Children's Books of 2022 In this real-life adventure, daredevil and groundbreaking journalists Nellie Bly and Elizabeth Bisland race against each other-and the clock-as they circle the globe by ship, train, and foot. Join these two stereotype-shattering reporters as they prove that not only is traveling around the world possible, but that women are just as curious, capable, and courageous as any man. Nellie Bly was an energetic and eager reporter, but she wasn't able to think of a good story for her editors. Wishing she was on the other end of the earth, Nellie had an inspiration-she would travel around the world, just like in the fictional adventure book Around the World in Eighty Days. When a fellow journalist, Elizabeth Bisland, heard about Nellie's plans, she decided to up the stakes-by beating Nellie in her own race! This exciting American history story about two pioneering women who paved the way for equality will inspire young readers. The perfect choice for parents and teachers looking for: Books for kids ages 7 - 10 about women's history Feminist picture books about historical women, and daring books for girls American history books for kids
Jounalists Nellie Bly and Elizabeth Bisland race the fictional Phileas Fogg and each other on a trip around the world in less than 80 days. Who will win?
the Italian side portal (wikimedia) The single bore, double track railway tunnel between Modane in France and Bardonecchia in Italy, under Mt Cenis, also known as the Fréjus Tunnel, was opened on 19 September 1871, at the time the world's longest tunnel. This status remained until 1 June 1882, with the opening of the 15 km Gotthard railway tunnel in Switzerland. In 1881, to protect the tunnel entrance on the French side against landslides, it was lengthened by more than a kilometre and the total length of the tunnel increased from 12.2 km to 13.64 km. Until 1980, shuttles to transport cars were put into service in the winter. This service ceased with the opening in July 1980 of the Fréjus road tunnel. See earlier post.
It's 125 years since intrepid young American journalist Nellie Bly, was the first person to go around the world in 72 days! She beat Jules Verne's 80 day limit.
Two Victorian women race against each other around the world, in the process countering the cultural inertia of their era.
It's 125 years since intrepid young American journalist Nellie Bly, was the first person to go around the world in 72 days! She beat Jules Verne's 80 day limit.
Daniel Crouch, a London-based specialist of antique maps and atlases, shares seven interesting tidbits, including the best country in which to buy them.
Unlock the secrets of chic hairstyling with our guide on how to style curtain bangs. Discover expert tips and elevate your look effortlessly!
I love this Grilled Vietnamese Chicken in Pho, on rice or in salads. The marinade permeates the chicken to make it succulent and delicious.
In our topsy-turvy, stressed-out world, true love may be the only thing we can count on. Looking for that special someone has become a priority for many.
Dive into a world where the quiet corners of the Mediterranean's sun-drenched tranquility blend with the enigmatic shadows of Gothic allure. This gallery
Taking a step back in time, this year we’re seeing a revival of the 70s when it comes to hair trends. These iconic styles revisit what we love most about he disco days with looks that include Curtain Bangs, The Shag, Farrah Fawcett Waves, and Disco Curls. Take a peek at each of these styles and be inspired for a new season of style.
These spicy noodles are inspired by a Chinese dish called Ants Climbing a Tree, named for the way the small pieces of ground pork (the "ants") cling to the noodles (the "tree"). The twist in these healthy noodles comes from adding vegetables like scallions and bok choy.
Portugal is a vast country made up of diverse landscapes. Its scenery is one of the many reasons we fell in love so quickly and why we've already been back twice since our initial visit. Due to its location on the Iberian Peninsula, Portugal has a seemingly endless coastline. This coastal country also boasts several island chains that are definitely worth a visit, including the Berlengas Islands, and the Azores , which we visited on a return trip! Just a short 20-minute drive from where we were staying in Obidos is the town of Peniche, and just a 7-mile boat
Great and easy one pot meal which starts on the stove and finishes in the oven! Greek lamb meatballs and brown rice is a healthy, complete meal full of the flavors of mint and thyme and finished with a crumble of feta.
4 simple ways to arrange flowers and plants in your garden to get that beautiful layered look that you want... even if you're a beginner!
A delicious recipe for Shrimp Enchiladas, filled with tender garlic shrimp, sweet corn, and lime zest, lathered in a flavorful Yellow Mole Sauce. Vegetarian-adaptable, with a video!
The Aligned Life teaches you how to manifest the right way! Stop feeling blocked & start manifesting the life you want >>
This 4-bed modern farmhouse plan has perfect balance with two gables flanking the front porch (10' ceilings, 4:12 pitch). A classic gabled dormer - for aesthetic purposes - is centered over the front French doors that welcome you inside. Board and batten siding helps give it great curb appeal. Vaulted ceilings in the great room are visible from the foyer. Step into the room and you'll find a fireplace on the right wall flanked by built-ins and views that extend across the rear porch and to the kitchen. The gourmet kitchen features a walk-in pantry, large prep island with seating for four, and a nearby formal dining room. For warmer months, enjoy the grilling porch just outside the kitchen. The restful master bedroom is quietly situated on the left side of the home, and boasts vaulted ceilings, a spacious bathroom with a large walk-in closet, and a separate tub and shower. The three secondary bedrooms are located on the opposite side of the home. Two share a Jack and Jill bath and the third has its own bathroom. The rear porch has access to a powder room which itself can access the mud room through a pocket door. A 3-car garage with a man door to the back yard completes the home. A 3-car garage - with a 2-car opening and a 1-car opening - gives you great room for your vehicles and gear. Choose the 2-car option and the dimensions change to 24' by 25'-8". Choose the Room Over Garage option and gain 632 sq. ft. of expansion space. If you select that option in combination with the 2-car garage the bonus room becomes 12' shorter in depth. Related Plan: Get a larger version with house plans 56535SM (2,841 sq. ft.) and 56539SM (2,951 sq. ft.). Get an alternate layout with 56521SM (3,127 sq. ft.) and 56529SM (3,346 sq. ft.), a smaller version with 56536SM (2,291 sq. ft.) a modern Acadian exterior with house plan 56527SM (2,789 sq. ft.).
Stuffed with a creamy spinach ricotta filling and baked in a flavorful basil vodka sauce, these spinach ricotta stuffed shells are easy to prepare and will impress everyone you serve them to!
A woman can have a million reasons to decide to give a hard pass to marriage, and it's not fair to question her choice. When you come across a woman who doesn't believe in marriage, there are certain things that you should probably avoiding saying…
“I am a doctor for injured, dilapidated homes,” the former Gucci designer says.
Angel food cake has always been a favorite dessert of mine, so I decided to make a vegan angel food cake version! This cake is all you have dreamed about and even more. I prepare this on every occasion I get. Notes An angel food cake is challenging enough to prepare, however, a vegan one is an even larger challenge. To ensure that this version turns great for you, I suggest that you read the whole article. It’s best to spare 10 minutes extra than to waste every penny and second make something that fails. Is This Vegan Angel Food Cake Worth Your Time and Energy? If you are on the hunt for a plant-based alternative to this divine sweet cake, this recipe is totally worth it. Similar to its original counterpart it has: -A greatly fluffy texture and fine taste -Lower calories compared to the real thing -Lower fat-one 1g of fat/slice You also need only 20 minutes to prepare it, despite the several steps involved in making it. Ingredients for Making Vegan Angel Food Cake: This recipe requires only six ingredients and therefore it’s best to measure these with caution and do not use any replacements if possible. Follow the recipe to a T! Aquafaba: a liquid leftover from cooked chickpeas that is a great replacement for egg whites. If you whip it up, it will become the best vegan “meringue”. Cream of tartar: this an acid substance that helps set aquafaba when beaten. Ground sugar: beat the regular sugar granules in a food processor or blender until finely dissolved into fine powder. Vanilla extract: for extra aroma and flavor Chickpea flour: a typical vegan egg replacer that helps set the meringue. All-purpose flour: use just one cup and tbsp of all-purpose flour passed through a sifter. Pin Ingredients: -¾ cup aquafaba (the liquid leftover from a can of chickpeas) -1 tbsp vanilla extract -1 cup & 1 tbsp all-purpose flour -1 cup granulated sugar -1 tbsp chickpea flour 1 ½ tsp cream of tartar Instructions: Preheat your oven at 330F/165C. Beat the granulated sugar into fine sugar in a blender or food processor. Place ¾ cup of aquafaba liquid into a big mixing bowl with vanilla extract and cream of tartar. Whip for 6 minutes minimum with a hand mixer initially on low and then slowly at higher speed. Incorporate the powdered sugar gradually in several parts while beating up the meringue on high speed for a couple of minutes. Once you have beaten the aquafaba for 8 minutes at least, grab a tbsp of the chickpea flour and beat for an extra minute or so. In three increments, gradually sift the flour combo into the egg mix through a mesh strainer, while carefully folding in with a rubber spatula after every part. To prevent any shrinking and loss of cake volume, don’t add the flour mixture in one part. Add gradually in multiple increments. Place and spread the batter into an unprepared 9X10” cake tubular pan. Shake the pan on a flat surface to even out the bottom. Bake your vegan angel cake until you add a toothpick and it turns out clean, for approx. 45-50 minutes. Take off the oven and let cool (while it’s still in the pan) for 2-3 hours. Once it’s cooled down, pass a small knife around the edges to gently detach the cake from the pan. If you wish, sprinkle with confectioner’s sugar. Serve with fresh berries on top and a small part of vegan whipping cream. See Also: Vegan Jamaican Ginger Cake Conclusion Hope you liked my vegan angel food cake recipe and enjoyed the cake as much as I have and my family & friends. Please let me know in the comments how this cake turned out for you, I will be happy to answer it!
Explore a range of decorative ceiling ideas to elevate your home's design. From textures to patterns, find inspiration for every room style.
In November 1889, two young female journalists, Nellie Bly and Elizabeth Bisland, set out for the journey of a lifetime—both with the goal to try to travel around the world in less than 80 days. Read about this amazing round the world journey of these two women, Nellie Bly and Elizabeth Bisland, and learn more about Victoria era travel.
