MyIgSource is committed to helping you and your loved ones manage life with primary immunodeficiency (PI). Learn more about what PI is and living with Ig (immunoglobulin) treatment. Find a support community to connect with and learn from people living with PI.
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A significant increase in norovirus outbreaks in the U.S. means those with primary immunodeficiency (PI) should exercise increased caution to protect from the virus.
Primary immunodeficienciesPrimary immunodeficiencies (aka, PIDs) are inherited, as opposed to the acquired secondary disorders. PIDs can arise as defects in the innate and/or adaptive immune systems.Defects in the innate system include: dysfunctional leukocytes, complement proteins, and toll-like receptors.Defects in the adaptive immune system include dysfunctional or absent T cells, natural killer cells, B cells, or antibodies (aka, immunoglobulins).Primary immunodeficiencies increase an individual's susceptibility to infection, allergy, and autoimmune disorders; they are often diagnosed in infancy or early childhood. Treatment: Primary immunodeficiencies of the adaptive system are often treatable with hematopoietic stem cell transplants or antibody therapy. Innate Immunity DefectsAdhesion deficiencies Impair leukocyte trafficking:Leukocyte adhesion deficiency 1 is due to defects in the CD 11/CD18 integrins, which adhere neutrophils to the vessel endothelium during recruitment.Leukocyte adhesion deficiency 2 is due to defects in the selectin receptor, which neutrophils use to roll along the vessel wall to the site of diapedesis. See acute inflammation for a reminder of leukocyte trafficking.Chediak-Higashi syndrome Defective phagosome-lysosome fusion prevents neutrophilic antimicrobial products from reaching their pathogen targets.Chronic granulomatous disease Caused by defects in NADPH oxidase; reactive oxygen species production and neutrophil respiratory burst are inhibited.Myeloperoxidase deficiency Impairs antimicrobial effects, though this deficiency tends to have less severe consequences.Dysfunctional complement proteins Interruption of the complement cascade, and, in many cases, leave individuals more susceptible to invasive meningococcal infections. C2 and/or C4 deficiencies interrupt the classical pathway, and are associated with the symptoms of lupus due to persistent immune complexes.Defects in C3 interrupt both classical and alternative pathways.Properd...
Warning signs of primary immunodeficiency
The Mighty partners with the Immune Deficiency Foundation to ask patients with primary immunodeficiencies (PI) what they wish others understood.
A reminder from #ChronicWarriors: You can be supportive without giving advice. #LymeDisease #Spoonie #FightStrong
World Primary Immunodeficiency Week, April 22-29, raises global awareness about genetic immune disorders. Join in advocating for PID care..
Different types of Immunoglobulin
Primary immunodeficiency diseases (or inborn errors of immunity) are a group of genetic diseases that impair the immune system. Learn more about symptoms and treatments.
It's often thought that trigeminal neuralgia only affects people over fifty. But young people, even children, can get trigeminal neuralgia
Myasthenia gravis is an autoimmune neuromuscular disease that results from antibodies attacking your body's muscle cells, causing weakness in the arms, legs ...
Immunoglobulin (Ig) replacement therapy treats antibody deficiencies by providing the person with antibodies, either intravenously (IVIG) or subcutaneously (SCIG), from blood plasma donated by healthy donors. This therapy is usually lifelong.
Have you ever thought about how old your cat would be in human years? So many of us have heard that if you take a dog or cat’s age and multiply it by 7 that ...
FIV or Feline Immunodeficiency Virus is a viral disease that affects cats exclusively (lentivirus group). This virus is the feline equivalent of human HIV.
Testing saliva for the presence of antibodies could be the new and simpler way to identify bacterial infections.
The parent of a medically complex child shares her response to others telling her "all kids get sick."
Family and friends of mum Claire Diss, 35, want to raise awareness of the disease because they say the NHS cannot provide suitable testing
The Facts About Cervical Cancer - When cancer begins in the cervix, also known as cervical cancer, it’s also known as invasive endometrial polyps. The cervix attaches the vagina to the upper portion...
