Anaphylactic Shock Pathophysiology - Free download as PDF File (.pdf), Text File (.txt) or read online for free. The document describes the allergic reaction process where allergens are identified by antigens, antibodies then bind with the antigens. This causes mast cells and basophils to release histamine which leads to cell fluid shifting, edema, swelling, and inflammation of the skin, eyes, lips and larynx. Additionally, it causes the release of bradykinin and leukotrienes resulting in vasodilatation, maldistribution of blood flow, increased capillary permeability, reduced venous return and cardiac output, decreased glomerular filtration and tissue perfusion, lower urine output and blood pressure, and potentially shock.