Some 10% of familial adenomatous polyposis (FAP) and 80% of attenuated polyposis (AFAP) cases remain molecularly unexplained. We scrutinized such cases by exome-wide and targeted methods to search for novel susceptibility genes. Exome sequencing was conducted on 40 unexplained (mainly sporadic) cases with FAP or AFAP from Finland. The DNA mismatch repair (MMR) gene MLH3 (MutL Homolog 3) was pinpointed and prompted a subsequent screen of ~1000 Swedish patients referred to clinical panel sequencing for colon tumor susceptibility. Three homozygous carriers of a truncating variant in MLH3, c.3563C>G, p.Ser1188Ter, were identified among the index cases from the Finnish series. An additional biallelic carrier of the same variant was present in the Swedish series. All four patients shared a 0.8-Mb core haplotype around MLH3, suggesting a founder variant. Colorectal polyps from variant carriers showed no instability at mono-, di-, tri-, or tetranucleotide repeats, in agreement with previous findings of a minor role of MLH3 in MMR. Multiple loci were affected by loss of heterozygosity, suggesting chromosomal instability. Our results show that a biallelic nonsense variant of MLH3 underlies a novel syndrome with susceptibility to classical or attenuated adenomatous polyposis and possibly extracolonic tumors, including breast cancer.

1967 Cats, Set of 6. Designs: 1s, Angora. 2s, Siamese, horiz. 3s, Abyssinian. 5s, Black European. 13s, Persian, horiz. 20s, Striped domestic.

AUSTRALIA - VICTORIA - 1901-10 KEVII £1 carmine-rose, wmk V1 crown sideways, perf 12½. VF MLH. ACSC V125, SG 399 cat £350. (P)

A classic and functional minimiser bra, featuring soft, flat straps with a comfortable underwire for optimum fit and wear. Brand: Triumph Hand wash 65% Polyamide, 26% Elastane (LYCRA®), 9% Polyester Please note: Do not tumble dry as the straps and rings could be damaged by the heat and break. *Lycra is a registered trademark of Invista.

AUSTRALIA - KANGAROOS - THIRD WMK - £1 Grey opt SPECIMEN type B. VF fresh MLH. SG 75s(var). ACSC 53x cat $4500. Very rare ACSC indicates 360 printed, but number known indicates only 1 sheet of 120 was distributed. Certificate can be obtained on request. (P)

MLH France Sc 122 (1906) Yvert 143 Xtra Fine ..Free Shipping..

AUSTRALIA - KANGAROOS - FIRST WMK - 10/- Grey & pink. VF MLH, appears MUH. SG 14 cat £900. ACSC 47A cat $2000. (P)

1967 Cats, Set of 6. Designs: 1s, Angora. 2s, Siamese, horiz. 3s, Abyssinian. 5s, Black European. 13s, Persian, horiz. 20s, Striped domestic.