The immunoglobulin D (IgD) role is not clear. Its function is with BCR.

While it’s true that most with HIDS have high Igd and it’s less common to rare in other fever syndromes, basing a diagnosis on IgD results becomes problematic when evaluating individual patients, especially considering that PFAPA, TRAPS, and FMF also have symptoms that are similar to HIDS.

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Different types of Immunoglobulin

Antibodies, also known as immunoglobulins, are proteins produced by lymphocytes as a result of interaction with antigens. IgG, IgM, IgA, IgD, and IgE.

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The main difference between IgG IgM IgA IgE and IgD is their structure and function. IgG has the highest opsonization and neutralization activities; IgM is

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