e17109 Background: Endometrial carcinoma is the most common gynecology malignancies in the worldwide. The clinical outcome of endometrial carcinoma is excellent, with disease specific survival rate over 90% in early stages. However, the prognosis of metastatic endometrial carcinoma is poor and the pattern of distant metastases has not been well characterized. In the present study, we sought to assess the incidence and prognosis of different distant metastatic sites in endometrial carcinoma. Methods: Patients who were diagnosed with endometrial carcinoma between 2010 and 2015 were identified according to the following criteria in the Surveillance, Epidemiology, and End Results (SEER) database: (1) confirmed age and older than 18 years old; (2) enrolled patients should have confirmed distant visceral metastatic status information. Kaplan-Meier analysis and log-rank tests were used to estimate the overall survival (OS) between difference groups. Data were analyzed with GraphPad Prism (version 7.01, GraphPad Software, USA), and R (version 4.3.1, R Development Core Team). Results: A total of 73328 patients with endometrial carcinoma were included. Median age of diagnosis was 62 years and 80.3% of patients were white. 92.8% of patents have received surgery. 4.2% of patients (3053/73328) suffered at least one site of distant metastases. The most common metastasis site was lung (1331/73328, 1.82%), followed by distant lymph nodes (1191/72703, 1.6%), liver (661/73328, 0.9%), bone (475/73328, 0.65%) and brain (133/73328, 0.18%). Median OS was 15 months, 4 months, 7 months, 9 months and 8 months for pure distant lymph node, brain, bone, lung and liver metastases, respectively. Furthermore, metastatic sites showed significant impact on OS in univariate analysis. Multivariate analysis with COX proportional regression model showed that distant metastatic sites were independent prognostic factors of OS. Conclusions: Lung is the most common distant metastatic site of endometrial carcinoma. Patients with pure distant lymph node metastasis exhibited the best overall survival, while patients with brain metastases had worst clinical prognosis compared with other metastatic sites.
PCOS women have an overall 17-fold higher risk of developing endometrial cancer. Here’s what women with PCOS need to know about endometrial cancer and how to reduce their risk.
Endometrial carcinosarcoma is a rare and aggressive high-grade endometrial carcinoma with secondary sarcomatous trans-differentiation (conversion theory). The clinical presentation and diagnostic work-up roughly align with those of the more common endometrioid counterpart, although endometrial carcinosarcoma is more frequently diagnosed at an advanced stage. Endometrial carcinosarcoma is not a single entity but encompasses different histological subtypes, depending on the type of carcinomatous and sarcomatous elements. The majority of endometrial carcinosarcomas are characterized by p53 abnormalities. The proportion of POLE and microsatellite instablity-high (MSI-H) is directly related to the epithelial component, being approximately 25% and 3% in endometrioid and non-endometrioid components. The management of non-metastatic disease is based on a multimodal approach with optimal surgery followed by (concomitant or sequential) chemotherapy and radiotherapy, even for early stages. Palliative chemotherapy is recommended in the metastatic or recurrent setting, with carboplatin/paclitaxel doublet being the first-line regimen. Although the introduction of immunotherapy plus/minus a tyrosine kinase inhibitor shifted the paradigm of treatment of patients with recurrent endometrial cancer, patients with endometrial carcinosarcoma were excluded from most studies evaluating single-agent immunotherapy or the combination. However, the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) approved the use of pembrolizumab and lenvatinib in endometrial cancer (all histotypes) after progression on chemotherapy and single-agent immunotherapy in MSI-H cancers. In the era of precision medicine, emerging knowledge on molecular endometrial carcinosarcoma is opening new promising therapeutic options for more personalized treatment. The present review outlines state-of-the-art knowledge and future directions for patients with endometrial carcinosarcoma. No data are available.
Uterine papillary serous carcinoma, or UPSC, is a form of cancer of the lining of the uterus. Here’s what you need to know about this rare but aggressive disease.
Cancer is an international interdisciplinary journal publishing articles on the latest clinical cancer research findings, spanning the breadth of oncology disciplines.
This book discusses various aspects related to the management of endometrial carcinoma. It is a compilation of researches conducted by experts around the world. It offers comprehensive and detailed notes on the advancement in analysis and therapeutic techniques in this field of gynecologic cancer. The book gives insight into the biology and genetics, modern imaging, surgery and therapies of endometrial cancer. With this book we intend to help experts dealing with this field.
Uterine papillary serous carcinoma, or UPSC, is a form of cancer of the lining of the uterus. Here’s what you need to know about this rare but aggressive disease.
The decision taken during the First International Congress on the Menopause in June 1976 to repeat the exercise 2 years later turned out to be a good one. In the last few years much work has been done on the subject of the menopause. I t is, of course, a subject of many facets, but of particular importance recently has been the work done as a result of the reports appearing in 1975 and 1976 alleging an increase in the incidence of endometrial carcinoma in women who had used oestrogens, and of other effects, some beneficial others deleterious, reportedly seen when oestrogens were administered. 1978 seemed the right time to re-assess the situation, and the Second Inter- national Congress on the Menopause provided a good platform. The congress was held in Jerusalem in June 1978. It took the form of a series of 12 workshops, each of which, within a prescribed framework, was planned and presided over by a moderator experi- enced in that particular field. The 12 moderators were free to organize their sessions in whichever way they wished, and to invite whoever they wished to present papers and to join in the discussions. In addition the workshops were open to anyone who wished to attend.
Endometrial cancer is a disease in which malignant (cancer) cells form in the tissues of the endometrium. . The endometrium is the lining of the uterus, a hollow, muscular organ in a woman's pelvis. The uterus is where a fetus grows. In most nonpregnant women, the uterus is about 3 inches long. The lower, narrow...
Learn how to protect yourself from the five most common types of cancer.
Uterine papillary serous carcinoma, or UPSC, is a form of cancer of the lining of the uterus. Here’s what you need to know about this rare but aggressive disease.
Uterine papillary serous carcinoma, or UPSC, is a form of cancer of the lining of the uterus. Here’s what you need to know about this rare but aggressive disease.
Dr. Neha Lalla is the best gynecologist in Dubai for women. She works at Garhoud's Prime Hospital in Dubai. Dial Our Number: +971 50 307 3225
Thelansis’s “Uterine Serous Carcinoma (USC) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Uterine Serous Carcinoma treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).
https://doi.org/10.18632/oncotarget.28409 Luke A. Rathbun, Anthony M. Magliocco, Anil K. Bamezai
Learn how a secretory endometrial biopsy is performed before you have tissue samples taken from the lining of your uterus.
The tomographic findings suggest an endometrial cancer. The biopsy proved to be an adenocarcinoma of the endometrium.
A visual mnemonic for malignancies that can cause cannonball pulmonary metastases
Uterine papillary serous carcinoma, or UPSC, is a form of cancer of the lining of the uterus. Here’s what you need to know about this rare but aggressive disease.
Uterine papillary serous carcinoma, or UPSC, is a form of cancer of the lining of the uterus. Here’s what you need to know about this rare but aggressive disease.
Uterine papillary serous carcinoma, or UPSC, is a form of cancer of the lining of the uterus. Here’s what you need to know about this rare but aggressive disease.
Uterine papillary serous carcinoma, or UPSC, is a form of cancer of the lining of the uterus. Here’s what you need to know about this rare but aggressive disease.
Four months ago, my world was turned upside down. I was diagnosed with endometrial cancer. I beat it and met hundreds of women who are fighting this fight. Hopefully, this article will provide valuable information.
Abnormalities of the Endometrium, Uterine Polyps Fibroids and Endometrial carcinoma, an informative guide with the ultrasounds included.
Mary Venvertloh of Quincy, Illinois thought she was suffering from a severe case of constipation, it wasn't....
Polycystic ovary syndrome (PCOS), as its name suggests, is a gynecological condition that is characterized by the presence of multiple cysts in the ovaries. The syndrome occurs due to a hormonal imbalance in the female
Menopause and belly fat are linked. Your body wants fat because fat cells make estrogen. Fight back with these food choices and this eating & exercise shift
Epidemiology The 6th most common malignancy in women worldwide. The 4th most common malignancy in women in developed countries. The most common gynecological malignancy in the western world. The me…