CREST syndrome is a condition that affects the connective tissue of the body. It is a form of systemic sclerosis, which affects the skin, causing it to harden and tighten. Learn more.

Crest Syndrome is one of the autoimmune conditions which affects the connective tissues that provide support to all the tissues and organs.

CREST syndrome is type of scleroderma is believed to be an autoimmune disorder. Mostly in lower arms and legs, below the elbows and knees, and sometimes affect the face and neck. Limited scleroderma…

The journey for Pat Oneill has been a long and frustrating road leading to her diagnosis of Raynaud’s secondary to CREST syndrome at age 74.

Learn about CREST syndrome & systemic sclerosis. What are causes, signs, symptoms, diagnosis, treatment & prognosis of CREST syndrome and systemic sclerosis

CREST syndrome is an acronym for 5 cardinal features of the condition namely: C - Calcinosis R - Raynaud's Phenomenon E - Esophageal Dysmotility S - Sclerodactyly T - Telangiectasia These 5 different signs and symptoms of the condition may...

Drs. Vishal Deshpande and Srikanth Jammalamadaka share a case of CREST syndrome in a woman of 30. Consolation aggravates, desires sweets and aggravation walking were among the symptoms leading to the simillimum.

CREST syndrome is an acronym for 5 cardinal features of the condition namely: C - Calcinosis R - Raynaud's Phenomenon E - Esophageal Dysmotility S - Sclerodactyly T - Telangiectasia These 5 different signs and symptoms of the condition may...

CREST syndrome is an acronym for 5 cardinal features of the condition namely: C - Calcinosis R - Raynaud's Phenomenon E - Esophageal Dysmotility S - Sclerodactyly T - Telangiectasia These 5 different signs and symptoms of the condition may...

It started with the hair-dryer on my feet. Friends called me a wuss for complaining about my freezing feet: like two ice blocks, even in summer.

The iliac crest is the most prominent part of the largest bone in the hip. Learn more about causes of iliac crest pain, treatment, how to recognize it, and exercises.

Systemic sclerosis or systemic scleroderma is an autoimmune disease affecting the connective tissues of the body. It is characterized by injuries to small arteries and thickening of the skin caused by an accumulation of collagen. Systemic scleroderma affects the skin of the hands, feet and the face, but also progresses to the kidneys, lungs, heart and gastrointestinal tract. Some of the common symptoms of systemic sclerosis include the CREST syndrome, hardening and scarring of the skin, impairment in lung function, joint pains, etc. Diagnosis is based on the presence of autoantibodies or through a biopsy examination. Therapies for systemic sclerosis include immunosuppressive drugs as well as glucocorticoids. This book explores the clinical aspects of systemic sclerosis in the present day scenario. It strives to provide a fair idea about this disorder and to help develop a better understanding of the latest advances in the understanding of this disease. It aims to equip students and experts with the advanced topics and upcoming concepts in this area.

Learn about primary and secondary Raynaud's, symptoms, diagnosis, and treatments. I also share my experience and self-management tips.

Pleural empyema refers to a collection of pus in the pleural cavity which may contain gas locules. Empyema is usually unilateral and most often occurs as a complication of pneumonia or perforated o...

Learn how biofeedback can Help individuals with Raynaud's - Discover effective techniques, scientific insights, and practical tips in this informative guide.

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An overabundance of fat along the top of the neckline, otherwise known as cresty neck, is an indicator of metabolic problems in your horse. In fact, researchers believe this type of regional fat deposit (nuchal crest adiposity) is a strong indicator of equine metabolic syndrome (EMS).

Ross Hauser, MD, Danielle R. Steilen-Matias, MMS, PA-C Iliolumbar ligament injury; Iliolumbar syndrome; Iliac crest pain syndrome You are an athlete or someone who does physically demanding work and you have low back, groin, and hip pain. You had significant enough pain that you needed the help of a health care specialist. During your consultation, you may have described the pain to your health provider as severe and acute at times and radiating out from the center of your low back to the top of your hip or pelvis, (the iliac crest) and into your groin region. As low back, …

What is Thoracolumbar Syndrome? Thoracolumbar (T/L) syndrome, also known as Maigne’s Syndrome, is an uncommon area of joint dysfunction which can present itself as iliac crest pain, sacroiliac pain, hip pain, and pubic pain (including the groin and testicular area). This is a result of joint hyperm

Read about a case study of a patient with CREST syndrome (limited scleroderma) successfully treated with regular therapeutic plasma exchange (TPE).

CREST syndrome is type of scleroderma is believed to be an autoimmune disorder. Mostly in lower arms and legs, below the elbows and knees, and sometimes affect the face and neck. Limited scleroderma…

Systemic sclerosis (SSc; scleroderma) is a disease in which inflammatory and fibrotic changes result in overproduction and accumulation of collagen and other extracellular matrix proteins, resulting in intimal vascular damage, fibrosis, and occasionally organ dysfunction affecting the gastrointestinal, lung, heart, and renal systems. There are two classifications of SSc—limited cutaneous or CREST (calcinosis, Raynaud’s, esophageal dysmotility, sclerodactyly, and telangectasias) syndrome, where skin thickening occurs mainly in the distal extremities and facial/neck areas and internal organ involvement, if present, occurs later in the disease process; and diffuse cutaneous disease where there is a more rapid progression of skin thickening from distal to proximal and organ involvement can be severe and occur early in the disease. As noted by various authors, there is no “crystal ball” into which one can look to see the outcome of the disease, and involvement varies significantly from one person to the next.

This serious disorder means a major lifestyle change for affected horses.

Ross Hauser, MD, Danielle R. Steilen-Matias, MMS, PA-C Iliolumbar ligament injury; Iliolumbar syndrome; Iliac crest pain syndrome You are an athlete or someone who does physically demanding work and you have low back, groin, and hip pain. You had significant enough pain that you needed the help of a health care specialist. During your consultation, you may have described the pain to your health provider as severe and acute at times and radiating out from the center of your low back to the top of your hip or pelvis, (the iliac crest) and into your groin region. As low back, …

07.31.12 *Post title not to be compared with Julia Robert's role in Pretty Woman* I've finally decided to own up to my blood tests. Several months ago, my rheumatologist told me that I have (or will have) Sjogren's Syndrome, a chronic autoimmune disease in which people’s white blood cells attack their moisture-producing glands. Although the hallmark symptoms are dry eyes and dry mouth, Sjögren’s may also cause dysfunction of other organs such as the kidneys, gastrointestinal system, blood vessels, lungs, liver, pancreas, and the central nervous system. Patients may also experience extreme fatigue and joint pain and have a higher risk of developing lymphoma. When my doctor explained the disease, he mentioned the dryness effect. Dry eyes and mouth ... I couldn't recall ever having those symptoms. But after connecting with others who live with Sjogren's, I've learned there really is much more to it than that. Dry skin (Maybe that's why I've been moisturizing like a fanatic) Fatigue (I always chalked this up to being a mom-of-3, but no matter how much sleep I get, I'm still tired. I used to have energy. Really, I did.) Ear pain (My ears have been "popping" a lot lately. It's annoying) Joint pain (You'd think with a titanium hip, my join pain would lessen. But, nope) Difficulty swallowing (yep) Always thirsty (yep) "Brain fog" - a lay term to describe fluctuating mild memory loss (I'm a tried and true blond, but it's possible) Celiac Disease (between 4.5% and 15% of people with Sjogren's also have Celiac Disease, which I do have a lot of symptoms for - I need to look into this further, but it's been on my mind. I've ignored it, because I don't really want to eat Gluten-free) I don't mean to seem like a hypochondriac, but all of these things make sense now. I also want to add that these symptoms have become new to me this year. I don't know if Sjogren's was brought on by the silcone in Mirena, or if it was something I was destined for. But I do know that these problems are new to me. I have also read that "silicone poisoning" causes Sjogren's Syndrome. Since symptoms of Sjögren’s mimic other conditions and diseases, Sjögren’s can often be overlooked or misdiagnosed. On average, it takes nearly seven years to receive a diagnosis of Sjögren’s. Lucky (or unlucky) for me, I was on a fast track for diagnosis, because my doctor's were trying to figure out why I developed Avascular Necrosis (though Sjogren's Syndrome is not a known cause of Avascular Necrosis). Last week, I was re-tested and my blood levels still indicated that I have Sjogren's Syndrome. I don't know why I thought that it would just go away. My original tests (in March) also indicated a clotting disorder. But with my tests from last week, those levels had come down significantly. That was a good thing, but it also makes me wonder what caused the clotting in the first place (hmmmm). I might go to see a hematologist just to completely rule out a clotting disorder. I guess what all this rambling sums up to is that I probably do have Sjogren's Syndrome. And until the blood tests reveal that I don't, I'm going to "work it" and "own it." I plan to start taking Plaquenil, which is what my doctor suggested to slow the progression of Sjogren's. Since using Mirena, I've been picky about any prescriptions, and I pay closer attention to side effects. I was nervous about Plaquenil because it's main side effect is vision impairment. I happen to have 20/20 vision and that is not something I want to forfeit. But other Plaquenil users say this hasn't been a problem for them, so if it'll save the rest of my body, I'm willing to give it a shot. Another interesting tidbit: Sjogren's Syndrome is what forced Venus Williams out of the U.S. Open last year (http://abcnews.go.com/Health/w_MindBodyNews/venus-williams-sjogrens-syndrome/story?id=14426884#.UBhluHCxpsM)

OBJECTIVE Bertolotti syndrome is a diagnosis given to patients experiencing low-back pain due to a lumbosacral transitional vertebra (LSTV). LSTVs cause altered biomechanics at the lumbosacral junction, predisposing these patients to degenerative disease. It has been proposed that these patients have additional non-osseous variation such as ligamentous differences in the lumbar spine. The iliolumbar ligament, which attaches from the iliac crest to the transverse process of L4 and L5, plays a significant role in reducing lumbar motion in all six degrees of freedom; therefore, altered ligament anatomy can have a significant impact on stability. The purpose of this study was to examine the iliolumbar ligament complex in patients with Bertolotti syndrome and anatomically normal controls to determine if underdevelopment of the iliolumbar ligament complex is seen in Bertolotti syndrome. METHODS This is a retrospective analysis of patients with Bertolotti syndrome and anatomically normal controls who received care at the authors’ institution between 2010 and 2020. Axial thickness of the iliolumbar ligament at the L5 vertebral level was assessed via MRI. Results were compared between the defective and normal side within unilaterally affected (Castellvi types IIa and IIIa) Bertolotti syndrome patients, between defective sides in bilaterally affected Bertolotti syndrome patients (Castellvi types IIb, IIIb, and IV), and between the affected side in Bertolotti syndrome patients and the corresponding location in normal controls. RESULTS A total of 173 patients were included in the study, 102 with Bertolotti syndrome and 71 controls. Among the Bertolotti patients, 49 had left LSTVs, 29 had right LSTVs, and 24 had bilateral LSTVs. For patients with unilateral defects, defective side ligaments were thinner than ligaments on the normal side (p < 0.05). For bilateral LSTVs, ligament thickness on each side was considered statistically equivalent (p < 0.05) and not significantly different from that in controls. CONCLUSIONS Bertolotti syndrome correlates to significant underdevelopment of the iliolumbar ligament corresponding to the side of the LSTV as compared to the ligament on the contralateral side. In patients with bilateral LSTVs, no difference in the iliolumbar ligament compared to that in controls was seen. Developmental changes in the iliolumbar ligament may further exacerbate the altered lumbosacral biomechanics seen in patients with unilateral LSTV, whereas bilateral LSTVs may still allow normal development of the ligament complex. Further research should be done to examine the discrepancies seen in this study.

According to the Scleroderma Foundation, scleroderma is a chronic systemic autoimmune disease characterised by hardening (sclero) of the skin (derma),