Cytokines are a variety of proteins or glycoproteins formed by various nucleated cells in the body. Learn more about the role of cytokines to restore balance in the body.
Mast cells are resident in the brain and contain numerous mediators, including neurotransmitters, cytokines, and chemokines, that are released in r...
Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune diseases, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.
Cytokine and Chemokine Networks in Cancer\" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.
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Cytokines and Chemokines in Infectious Diseases Handbook PDF Free Download by MALAK KoTB
Dengue viruses (DENV), a group of four serologically distinct but related flaviviruses, are responsible for one of the most important emerging viral diseases. This mosquito-borne disease has a great ...
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A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.
This book provides an overview of some of the latest developments in the medical sciences, with particular emphasis on the experimental and theoretical aspects of modern medicine. In recent years, researchers working in applied health sciences have been able to identify diseases indicated by chemokines. Among the topics discussed in this book are chemokines affecting platelet functions, cytokine levels, and oxidative stress parameters in COVID-19, chemokines at the intersection of diabetes-tuberculosis synergy, chemokines in periodontal diseases, pathogenic links between hepato-digestive disorders and periodontal conditions, and IL-inflammatory carcinogenesis. Other areas included are the role of 23 receptor gene variations, the relationship between interleukin-5 Receptor polymorphism, and immunological parameters in children with asthma. The book's primary target audience includes students, researchers, medical practitioners, dentists, pharmacologists, and professionals interested in related fields. The book has been written by expert international scientists active in research in the health and applied sciences. We hope it will increase scientists' knowledge of the complexity of some medical approaches, and encourage both professionals and students to devote part of their future research to understanding the mechanisms and applications of chemokines. | Author: Murat Sentürk | Publisher: Intechopen | Publication Date: Mar 22, 2023 | Number of Pages: 140 pages | Language: English | Binding: Hardcover | ISBN-10: 1803561734 | ISBN-13: 9781803561738
Mast cells are resident in the brain and contain numerous mediators, including neurotransmitters, cytokines, and chemokines, that are released in r...
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Chemokines are a class of secreted molecules that induce chemotaxis (migration) of target cells. Chemokines and their receptors play essential roles in immunology during inflammation and in homeostasis.
Flonase Sensimist Allergy Relief Nasal Spray provides all-day relief for even the worst seasonal, year-round, indoor and outdoor allergies, all in a gentle mist you'll barely feel. Unlike most allergy pills, Flonase Sensimist relieves your most severe allergy symptoms, including sneezing, itchy nose, runny nose and itchy, watery eyes, plus nasal congestion. Flonase Sensimist is a 24 hour allergy relief medicine that contains fluticasone furoate, delivered with a patented bottle specially designed for a unique scent free and virtually drip free allergy nasal mist. This allergy medicine stops your body from overreacting to allergens all season long, outperforming a leading non-drowsy allergy pill.* Flonase Sensimist provides our most advanced spray technology with an ultra lightweight mist for 24-hour all-in-one allergy relief.This non drowsy allergy relief medicine is formulated for adults and children 12 years of age and older. Before using this allergy medicine, blow your nose. Shake the bottle, prime it by spraying until a fine mist appears, then spray twice into each nostril one to two times daily as needed.* Total nasal symptoms vs. single-ingredient 180 mg fexofenadine.
This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry.
In the article "Signaling Modulators in Bone Marrow Microenvironment and HSC Fate," V. P. Kale delves into the intricate signaling mechanisms in the bone marrow microenvironment that regulate the fate of hematopoietic stem cells (HSCs). The author highlights the critical role of various signaling modulators, including cytokines, chemokines, growth factors, and extracellular matrix proteins, in HSC maintenance, proliferation, and differentiation. He also discusses the potential implications of abnormal signaling pathways in HSC fate and the development of hematological disorders such as leukemia. This article is a valuable resource for researchers and clinicians interested in the molecular mechanisms underlying HSC function and the potential therapeutic targets for hematological diseases. | Author: V. P. Kale | Publisher: Independent Author | Publication Date: Apr 05, 2023 | Number of Pages: 126 pages | Language: English | Binding: Paperback | ISBN-10: 2353691676 | ISBN-13: 9782353691678
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Activated oligodendrocytes progenitor cells (OPCs) following an experimental demyelination lesion in the white matter of the brain mimicking injury seen in Multiple Sclerosis. OPCs shift into an “a…
Chemokines are a class of secreted molecules that induce chemotaxis (migration) of target cells. Chemokines and their receptors play essential roles in immunology during inflammation and in homeostasis.
Flonase Sensimist Allergy Relief Nasal Spray provides all-day relief for even the worst seasonal, year-round, indoor and outdoor allergies, all in a gentle mist you'll barely feel. Unlike most allergy pills, Flonase Sensimist relieves your most severe allergy symptoms, including sneezing, itchy nose, runny nose and itchy, watery eyes, plus nasal congestion. Flonase Sensimist is a 24 hour allergy relief medicine that contains fluticasone furoate, delivered with a patented bottle specially designed for a unique scent free and virtually drip free allergy nasal mist. This allergy medicine stops your body from overreacting to allergens all season long, outperforming a leading non-drowsy allergy pill.* Flonase Sensimist provides our most advanced spray technology with an ultra lightweight mist for 24-hour all-in-one allergy relief.This non drowsy allergy relief medicine is formulated for adults and children 12 years of age and older. Before using this allergy medicine, blow your nose. Shake the bottle, prime it by spraying until a fine mist appears, then spray twice into each nostril one to two times daily as needed.* Total nasal symptoms vs. single-ingredient 180 mg fexofenadine.
Pregnant women with higher levels of inflammatory cytokines and chemokines, proteins that control communication between cells of the immune system, may be at significantly greater risk of having a child with autism combined with intellectual disability, researchers have found.
ObjectivesThis explorative study analyses interrelationships between peripheral compounds in saliva, plasma, and muscles together with body composition varia...
This volume is designed to provide an understanding of current and potential therapies for osteoporosis. The opening chapter introduces the cells of bone and their interactions. Several following chapters describe factors affecting bone including systemic hormones with significant effects on bone, and local mediators including growth factors, prostaglandins, cytokines and chemokines. Topics that have commanded particular attention recently are calcium, FGF-23, nervous system bone interactions. Drugs that cause bone loss provide important information on mechanism as well as therapeutic considerations. An overview of the genetics of bone disorders and a discussion of the pathophysiology of osteoporosis establish the clinical context. The final chapters discuss current and potential osteoporosis treatments.
Chemokines are a class of secreted molecules that induce chemotaxis (migration) of target cells. Chemokines and their receptors play essential roles in immunology during inflammation and in homeostasis.
