The Anti-Histone Antibodies Test is a blood test that detects antibodies against histones, and proteins associated with DNA in the cell nucleus. It helps in diagnosing autoimmune conditions like drug-induced lupus or certain types of arthritis.   Anti-Histone Antibodies Test Here are the basic details of the Anti-Histone Antibodies Test. Test Name Anti-Histone Antibodies Test Also Known As Histone Antibodies Test Type Blood Test Purpose Detect Autoimmune Disorders Sample Type Blood Sample Preparation None Fasting Not Required Gender All Age Group All Normal Value Negative (No Antibodies Detected) Reporting Time Within 24 hours Cost 1000-2000 INR* *Price range may vary as per location, lab type, and procedure of lab test.   Anti-Histone Antibodies Test Means The Anti-Histone Antibodies test measures the presence and concentration of antibodies against histones in a person's blood. Histones are proteins associated with DNA in the cell nucleus and play a role in gene regulation. This test is crucial for diagnosing autoimmune diseases like systemic lupus erythematosus (SLE) and drug-induced lupus. Results are reported as the presence or absence of these specific antibodies and their concentration, if present. Abnormal results may indicate autoimmune disorders affecting the connective tissues. The test aids in diagnosing and monitoring autoimmune conditions.   Anti-Histone Antibodies Test Purpose The purpose of the Anti-Histone Antibodies Test is to: Diagnose autoimmune diseases like systemic lupus erythematosus (SLE). Detect the presence and concentration of anti-histone antibodies. Monitor autoimmune disorders affecting connective tissues. Assess treatment effectiveness and disease progression. Aid in the management of autoimmune conditions. Facilitate targeted medical interventions.   Anti-Histone Antibodies Test Preparation Here is the basic preparation for the Anti-Histone Antibodies Test.   Before Test No specific dietary restrictions. Inform the healthcare provider of any medications or medical conditions. Understand the test's purpose and its relevance to autoimmune disease diagnosis.   During Test No specific actions are required during the test.   After Test Follow any post-test instructions given by the healthcare provider. Discuss the results and their implications for autoimmune disease diagnosis and management. Be prepared to follow up with additional tests or treatments as recommended.   Anti-Histone Antibodies Test Procedure Here is the basic Anti-Histone Antibodies Test Procedure. The Anti-Histone Antibodies Test involves collecting a blood sample from the patient, typically from a vein in the arm. The collected blood is processed in the laboratory to isolate the serum. The laboratory technician uses specific techniques, such as enzyme-linked immunosorbent assay (ELISA), to detect the presence and concentration of anti-histone antibodies. Test results are reported as the presence or absence of these antibodies and their concentration if detected. The procedure is crucial for diagnosing autoimmune diseases affecting connective tissues. Accurate results assist in managing autoimmune conditions effectively.   Anti-Histone Antibodies Test Result Here is the basic reading of the Anti-Histone Antibodies Test results. Check the test report for the presence or absence of anti-histone antibodies. A positive result indicates the presence of these antibodies. The concentration is typically not provided in a binary result, but the presence suggests possible autoimmune conditions affecting connective tissues. Discuss the results with a healthcare provider for further evaluation and management.   Anti-Histone Antibodies Test Positive Result Report Format Anti-Histone Antibodies Positive Test Report Anti-Histone Antibodies Test Positive Result Report   Anti-Histone Antibodies Test Negative Result Report Format Anti-Histone Antibodies Negative Test Report Anti-Histone Antibodies Test Negative Result Report   Anti-Histone Antibodies Test Normal Range Here is the normal range of the Anti-Histone Antibodies Test Value Explanation of Results <1.0 Negative 1.0-1.5 Weak Positive 1.6-2.5 Moderate Positive >2.5 Strong Positive   Anti-Histone Antibodies Test Interpretation Here is the Interpretation of the Anti-Histone Antibodies Test. Test Result Interpretation Positive Elevated antibodies Negative Antibodies absent   Anti-Histone Antibodies Test Positive Results Here are the potential causes of Anti-Histone Antibodies Test Positive Results. Potential Causes Description Drug-Induced Lupus Some medications, such as hydralazine and procainamide, can lead to drug-induced lupus with positive anti-histone antibodies. Idiopathic or Autoimmune Disorders Positive results may be associated with autoimmune diseases, such as systemic lupus erythematosus (SLE) or idiopathic cases. Inflammatory or Connective Tissue Diseases Conditions like rheumatoid arthritis or mixed connective tissue disease may lead to positive results. Infections Certain infections, like viral hepatitis, may trigger the production of anti-histone antibodies. Environmental or Occupational Exposure Exposure to environmental toxins or occupational hazards can lead to positive anti-histone antibodies. Medications Some medications used to treat conditions like cancer and autoimmune diseases can induce the production of anti-histone antibodies. Positive anti-histone antibody results typically warrant further investigation to determine the underlying cause and to guide treatment decisions. A healthcare professional should be consulted for a comprehensive evaluation.   Anti-Histone Antibodies Test Negative Results Here are the potential causes of Anti-Histone Antibodies Test Negative Results. Potential Causes Description Absence of Autoimmune Conditions Negative results may suggest the absence of autoimmune diseases associated with anti-histone antibodies. No Drug-Induced Lupus A lack of histone antibodies may indicate that drug-induced lupus is not present. No Infections The absence of certain infections that can trigger anti-histone antibody production. No Environmental or Occupational Exposure The individual may not have been exposed to relevant toxins or occupational hazards. Medication History Negative results may be due to the absence of medications known to induce anti-histone antibodies. Healthy Immune System A well-functioning immune system may not produce anti-histone antibodies in the absence of relevant triggers. Negative anti-histone antibody results are typically reassuring, but further clinical evaluation may be necessary if the suspicion of autoimmune or drug-induced conditions remains. Consulting a healthcare professional is essential for proper interpretation and diagnosis.   Specimen Requirements For Anti-Histone Antibodies Test Here are the specimen requirements for the Anti-Histone Antibodies Test. Specimen Serum Volume 1 ml Container Red-top tube or gel-barrier tube Collection Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. Storage Refrigerate or freeze. Sample Stability Temperature Period Room temperature 14 days Refrigerated 14 days Frozen 14 days Causes for Rejection Hemolysis; icterus; lipemia; bacterial contamination.   Anti-Histone Antibodies Test is Safe? The Anti-Histone Antibodies Test is safe, involving a routine blood sample collection conducted by trained professionals. The test's risks are minimal, with potential side effects limited to mild discomfort or bruising at the blood draw site. It is considered a safe diagnostic tool used for the detection of autoimmune conditions.   When Do You Get Anti-Histone Antibodies Test Results?  Anti-Histone Antibodies Test results are typically available within 24 hours, depending on the laboratory's processing speed. Patients can expect to receive their test results from their healthcare provider once the analysis is finished.   Anti-Histone Antibodies Test Limitation Here is the basic limitation of Anti-Histone Antibodies Test. The presence of anti-histone antibodies does not confirm a specific autoimmune disease. Results may not capture fluctuations in antibody levels over time. Limited to detecting anti-histone antibodies and may not identify other relevant autoantibodies. Interpretation can be challenging due to variations in antibody profiles. Positive results require clinical correlation for a definitive diagnosis.   Anti-Histone Antibodies Test Risk Factors Here are some of the risk factors of the Anti-Histone Antibodies Test. Risk factors may include autoimmune diseases like systemic lupus erythematosus (SLE). Medications or medical conditions that can cause drug-induced lupus. Previous exposure to drugs or environmental factors associated with lupus. Demographic factors may influence antibody prevalence, such as age and gender. Inaccurate results can occur if the test is not conducted correctly or interpreted in isolation.   Doctor Recommendations After Anti-Histone Antibodies Test Result  Here are the Doctor's recommendations or consult a specialist after the Anti-Histone Antibodies Test. Test Result Doctor to Visit Reason to See Doctor Positive Rheumatologist Evaluate autoimmune or drug-induced conditions. Negative General Practitioner Confirm no histone antibodies presence.   Anti-Histone Antibodies Test Price Here are the estimated Anti-Histone Antibodies Test Prices in India with different top cities: City Price Range (INR)* Mumbai 1000-2000 New Delhi 1200-2000 Bangalore 1000-2000 Hyderabad 1200-2000 Kolkata 1000-2000 Pune 1200-2000 Lucknow 1000-2000 Noida 1200-2000 Surat 1200-2000 Gurugram 1000-2000 Patna 1200-2000 Chennai 1000-2000 Jaipur 1200-2000 Ahmedabad 1000-2000 *Anti-Histone Antibodies Test Prices are approximate and vary depending on a specific laboratory or healthcare facility.   Summary Overall, Anti-Histone Antibodies Test is critical for diagnosing and managing autoimmune conditions affecting connective tissues. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.   Reference Anti-Histone Antibodies - Wikipedia [1]. Anti-Histone Antibodies Test - Labcorp [2].