This slide show provides an overview of acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) and treatment-related acute myeloid leukemia (tAML). It also describes the causes, risk factors, and symptoms of AML-MRC and tAML. Both AML-MRC and tAML are “secondary” types of AML because they occur after a person has had MDS or another type of cancer. AML that starts abruptly with no known prior exposure to chemotherapy or radiation and no prior cancer diagnosis is called “de novo” AML and is discussed in another segment in this series.