Definition Osteomyelitis is a pyogenic bone infection. Risk Factors Trauma or secondary infection (most commonly Staphylococcus aureus). Blood-borne (hematogenic) osteomyelitis is more common in children after a throat infection. Resulting from orthopedic surgical procedures is more common in older persons. Pathophysiology Circulation of infectious microbes through the bloodstream to susceptible bone leads to inflammation, increased vascularity and edema. The organisms grow, pus forms within the bone, and abscess may form. This deprives the bone of its blood supply, eventually leading to necrosis. Assessment/Clinical Manifestations/Signs And Symptoms Localized bone pain Tenderness, heat and edema in the affected area Guarding of the