Tried and true folk remedies Early Appalachian settlers didn’t have access to health care. The nearest town with a real doctor might be days away, so they had to rely on themselves and whatever nature provided. As a result, they learned to make use of the natural medicines they found around them: roots, leaves, bark, flowers, fruit and seeds made into salves and tinctures. Even today, many Appalachian natives prefer to administer their own remedies rather than trust a doctor’s care.