Ross Hauser, MD, Danielle R. Steilen-Matias, MMS, PA-C In our many years of helping people with chronic pain conditions, we have seen many patients with Ischial tuberosity pain syndrome or buttock pain. We have also seen the many causes of this problem. The most common cause of pain at the cheek line in the buttock area is weakness in the structures that attach to the ischial tuberosity. The condition that is manifested by buttock pain and tenderness over the ischial tuberosity is known in traditional medical lingo as ischial bursitis. A bursa is a fluid-filled sac that allows tendons and …