Are you interested in learning more about the building blocks of the universe? John Ellis, Clerk Maxwell Professor of Theoretical Physics at King’s College London and leading physicist at CERN will be speaking at Laurentian University's Fraser Audito
Metal Mercury: Folklore, Symbolic Significance. Alchemy, Communication, Transformation. Mythology, Symbolism, Cultural Beliefs. Crystals
By Dr Katie Mack
Throughout history, wise minds and storytellers have encapsulated profound insights into memorable quotes with life lessons. Life constantly offers valuable lessons that shape our journey and guide our growth. Explore this curated selection of life lesson quotes that draw from the wells of literature, philosophy, and even pop culture. Let us know your favorite life […]
Elemental Dance Magick is a type of embodied ritual where we can alchemize the energy both in and around us in order to cultivate a relationship with the natural world and embody our highest potential.
Are you interested in learning more about the building blocks of the universe? John Ellis, Clerk Maxwell Professor of Theoretical Physics at King’s College London and leading physicist at CERN will be speaking at Laurentian University's Fraser Audito
The idea that free fetal DNA is present in the maternal blood is quite old and dates back to the end of 90s when, starting from the observation that cancer cell DNA could be found freely circulating in the human blood serum, Lo et al. demonstrated that fetal cell-free DNA could be detected as well starting from a specimen of mother blood (see the original paper). A nice overview of prenatal technology advances can be found on this article published in Wired. After this discovery several studies emerged and confirmed the possibility to use this easy accessible fetus DNA to detect well-known chromosome abnormalities previously diagnosed by invasive and risky procedures such as amniocentesis or chorionic villus sampling (CVS). In the first years of the new millenium techniques based on free circulating fetal DNA have attracted increasing attention for Rhesus D (RhD) genotyping and detection of chr 21 and cur 18 trysomies (see this review on Nature). Since they have proved to be as accurate as the classical tests requiring either amniocentesis or CVS but as low-risk as a blood draw, a commercial test kit based on this principle first hit the market in October 2011. Known as cell-free fetal DNA testing, it’s now offered by Sequenom, Verinata, and Ariosa Diagnostics The main advantages in detecting free fetal DNA from maternal blood are the quick and early response and the total absence of risk for the fetus itself. In fact fetal DNA could be detected as early as the 6th week of of pregnancy and the test simply requires a sample of mother's blood. This is a great achievement in the management of difficult pregnancies, thus easing off stress from parents' mind due to the doubtful choice between the risk of having a severely affected child and the risk of impairing a healthy fetus with an invasive procedure. Moreover an early response leaves more time for counseling and decision making process. The cell-free fetal DNA tests are by now limited to the detection of some well-known trisomy related conditions (Down, Edwards and Patau syndromes) and few other chromosomal abnomalities such as Klineferter or Turner syndromes. Moreover, despite its advantages and reliability, cell-free fetal DNA testing is still not diffused as a clinical practice and sometimes it's even not mentioned by physicians, so that the requests are often driven by the mothers themselves, looking online for a safer test. At the end of November 2012, the American Congress of Obstetricians and Gynecologists released a long-awaited opinion on the cell-free fetal DNA test. The group recommended it for patients at an increased risk for chromosomal defects, including those over age 35 and those with a history of trisomy pregnancies. These guidelines hopefully will make doctors more aware of the new test (many ob-gyns apparently have never even heard of it). New and rapid improvements in cell-free fetal DNA analysis will now come from applying NGS sequencing techniques, potentially leading to a new era of prenatal genomic diagnosis: deeper, faster, and risk free. In the 2012 a paper published on Science Translational Medicine demonstrated the feasibility of Whole-Genome Sequencing of fetal DNA extracted from mother's blood. The investigators integrated the haplotype-resolved genome sequence of the mother, the shotgun sequence of the father, and the deep sequencing of cell-free DNA in maternal plasma (maternal and fetal) to non-invasively predict the whole-genome sequence of a fetus. This approach requires a paternal sample to determine the fetal genome, which is a practical limitation to its clinical application. Another paper on Nature goes even further, eliminating the need for a paternal sample. Shotgun sequencing of the plasma cell-free DNA was performed, and the relative amounts of parental haplotypes were measured by counting the number of alleles specific to each parental haplotype (‘markers’). The paternally inherited haplotypes were reconstructed by detection of paternal-specific alleles, followed by imputation at linked positions using reference haplotypes from the 1000 Genomes project. This method allowed deduction of the inheritance of each parental haplotype and construction of the full inherited fetal genome. Moreover, the authors were able to detect in the DNA of the fetus a deletion on chr 22 responsible for Di George syndrome. Although technical and analytical challenges remain, in particular to correctly detect de-novo fetal genetic variations, these studies open new possibilities to apply cell-free fetal DNA test also for the identification of point mutations and other small rearrangements. A complete review on recent advancements in genomic prenatal diagnosis is given in this review published on Trends in Genetics. There are no doubts that prenatal DNA-based diagnosis will develop rapidly and that WGS of fetal DNA will became feasible and accurate in short times. This rises one more ethical and practical questions on how the genetic data will be managed and stored and on which information should be reported. The leading opinion by now is that only proved disease causing variations will be reported and many suggest to limit the list even further to only those mutations with severe consequences. The main concern in fact is to avoid that reproductive selection is applied also in the case of mild pathologies, or even worst based on unwanted characters based on cultural background. On the other hand, one advantage of having whole genome information is the possibility to adopt therapies or special life habits for conditions for which an early intervention could limit or avoid symptoms. Prenatal genome sequencing also poses the question on who is the owner of the data, or at least who is responsible for it. The test actually acquire information on a subject that can't give his consent and that potentially may be unwilling to know its DNA code at all when its grown up. But these information could also have a great benefic impact for the subject, since they one day may reveal details essential for his health as research constantly upgrade our knowledge about functional impact of genetic variants. So who is eventually in charge for the updates and who will decide on genetic information access? A possible solution could be some kind of encryption strategy (with a decryption code available to the owner only) that guarantees information security. For example I found an interesting solution (developed by Emiliano de Cristofano when he was at the University of California) that also allows for selective decryption of DNA sequence, giving access to a specific region while leaving the rest of the genome unrevealed. Promises and questions!
Star Wars created such iconic characters. How can you create characters as iconic and shimmering as Han, Leia, Chewie, or R2D2? There are four basic building blocks needed to create a character tha…
Dive into the captivating world of matter with this engaging non-fiction reading for middle school students, written to accommodate our lower readers. Designed to complement Unit 1: Introduction to Matter and Lesson 2: What Properties Describe Matter?, this resource explores the fundamental concepts of physical and chemical properties in an accessible and informative manner. This reading introduces students to the diverse characteristics that define matter, from its physical attributes like color, texture, and density, to its chemical properties such as reactivity and flammability. Through clear explanations, vivid examples, and relatable real-world applications, students will deepen their understanding of the building blocks of our universe. Note: This reading can be purchased as part of the "Unit 1: Introduction to Matter" package, which is coming soon. Stay tuned for an immersive learning experience that will captivate your students' curiosity and ignite their passion for the wonders of matter!
Welcome to The Homeschool Scientist's Chemistry Resource Page. This page contains links to all chemistry related information and activities published by
A block of graphite is made up of carbon atoms. Each carbon atom has a dense central nucleus made up of protons and neutrons. Protons and neutrons are made up of different combinations of quarks.
About the Book "A book exploring the world of the very small, delving deep into the microscopic spaces just beneath our skin"-- Book Synopsis Jason Chin, winner of the Caldecott Medal for Watercress, dives into the microscopic building blocks of life in this companion to the award-winning Your Place in the Universe. In Your Place in the Universe, Jason Chin zoomed outward, from our planet, solar system, and galaxy to the outer reaches of the observable universe. Now, Chin reverses course, zooming in past our skin to our cells, molecules, and atoms, all the way down to particles so small we can't yet even measure them. Like its companion, The Universe in You is a mind-boggling adventure that makes complex science accessible and enjoyable to readers of any age. Impeccably researched, wholly engrossing, and with extensive backmatter for additional learning, The Universe in You is another knockout from the award-winning creator of Redwoods, Grand Canyon, and other distinguished works of nonfiction for young readers. An American Library Association Notable Children's BookA Kirkus Reviews Best Book of the YearA Horn Book Fanfare TitleA School Library Journal Best Book of the YearA Junior Library Guild Gold Standard Selection Review Quotes ★ "Giving the biggest impact to these tiniest bits are full-page watercolor-and-gouache illustrations in fine detail, with an illustrator's note explaining methods for depicting and coloring particles too miniscule for humans to visualize. . . . stunning visuals. . . ."--Booklist, Starred Review ★ "Explained clearly and portrayed with dazzling precision. Ending lines weave scientific revelation into a message of profound inspiration. . . ."--Publishers Weekly, Starred Review ★ "Whether in the writing or page after page of cascading spreads drawing the eye in, science and poetry create a flawless blend of information, delivered with grace and confidence. . . . This book is a proper revelation, putting the 'you' in universe and giving children a way to grasp the infinity of the world and every particle of the planet. Exquisite."--School Library Journal, Starred Review ★ "The art's evocative detailing and dynamic compositions create vivid impressions of realism and movement that will carry viewers down to the point where size and location lose their meanings and then back around to the wide-eyed young observer. Another fantastic voyage from an accomplished author/illustrator, creatively presented."--Kirkus Reviews, Starred Review ★ "Chin cleverly presents a tiered experience that targets at least three levels of audiences. . . . In encouraging inquisitive minds, Chin transforms the impossible into the imaginable."--Shelf Awareness, Starred Review "Chin's stunning watercolor and gouache illustrations, colorfully detailed and scientifically accurate, employ perspective to draw readers into observations of life and matter within the smallest possible spaces."--The Horn Book "[A] gorgeously rendered nonfiction picture book with a poetic heart. . . . Chin's superb and richly detailed illustrations keep this title elevated. . . . Put this book in the hands of teachers seeking a framework for their biology units."--School Library Connection "Youngsters will appreciate the speed at which Chin moves through the universe, changing the scale with each page flip, while insets of further facts and details will intrigue aspiring scientists who want to sit with the matter (pun fully intended). Chin's characteristically detailed art is ideal to capture and delineate the tiny and unseeable. . . . a valuable addition to multiple science units."--The Bulletin of the Center for Children's Books About the Author Jason Chin is a celebrated author and illustrator of children's books. He received the Caldecott Medal for his illustrations in Andrea Wang's Watercress, a Newbery Honor book and APALA award winner. His book Grand Canyon was awarded a Caldecott Honor, a Sibert Honor, and the NCTE Orbis Pictus Award. His other acclaimed nonfiction titles--Coral Reefs, Redwoods, Gravity, and Island: A Story of the Galapagos--have received numerous starred reviews and other accolades. He is also the illustrator of Stephanie Parsley Ledyard's debut title Pie Is for Sharing and Miranda Paul's Water is Water and Nine Months: Before a Baby is Born, the latter a Boston Horn Globe Honor Book. He lives in Vermont with his wife and children.
Benefits of learning using Flash Cards : Quick and easy to use: Flashcards are designed to be quick and easy to use, making them a great tool for learning on the go or in short bursts of time. Active learning: Flashcards encourage active learning, which means students are actively engaging with the information and testing their knowledge, leading to better retention and understanding. Repetition: Flashcards are designed for repetition, allowing students to review and practice the information multiple times until they have mastered it. Memorization: Flashcards are a great tool for memorization because they are concise and easy to review, making it easier for students to retain the information. Personalization: Flashcards can be easily personalized to suit the individual learning needs of each student, enabling them to focus on the areas they need to improve. Portability: Flashcards are small and portable, making them easy to carry around and review anytime and anywhere, making learning a more continuous process. Interactive: Flashcards can be made interactive and fun, for instance with games, quizzes, or digital enhancements, thus making the learning process more engaging.
Bring understanding into your everyday life using the synergy of sacred geometry to enhance your personal healing and awakening. Sacred geometry is the Light language of the universe and is the building blocks of creation. This new and unique system includes 49 striking cards, a comprehensive guidebook, and is a tool to learn and practice creating beautiful healing grids for you and loved ones. You can also do simple or comprehensive guided card readings. It can even be extended to Earth’s restoration. These methods teach not only the simplicity and complexities of geometric symbols, and using them to connect to the universe, but show how they can be utilized personally and professionally to gain profound inner knowing—awakening your cells and ultimately the DNA that lies dormant within. Identify your own blueprint and cell structure. Learn how to incorporate animal totems, colors, sounds, frequencies, vibrations, numbers, and crystals to enhance your own geometric essence. Includes three new frequency cards and a Sacred card!Card dimensions: 3 7/8" x 5 7/8" Bring understanding into your everyday life using the synergy of sacred geometry to enhance your personal healing and awakening. Sacred geometry is the Light language of the universe and is the building blocks of creation. This new and unique system includes 49 striking cards, a comprehensive guidebook, and is a tool to learn and practice creating beautiful healing grids for you and loved ones. You can also do simple or comprehensive guided card readings. It can even be extended to Earth’s restoration. These methods teach not only the simplicity and complexities of geometric symbols, and using them to connect to the universe, but show how they can be utilized personally and professionally to gain profound inner knowing—awakening your cells and ultimately the DNA that lies dormant within. Identify your own blueprint and cell structure. Learn how to incorporate animal totems, colors, sounds, frequencies, vibrations, numbers, and crystals to enhance your own geometric essence. Includes three new frequency cards and a Sacred card!Card dimensions: 3 7/8" x 5 7/8" 49 healing cards and guidebook exploring sacred geometry, a system to understand the building blocks of creation 49 healing cards and guidebook exploring sacred geometry, a system to understand the building blocks of creationMethods teach geometric symbols and how to grid to promote healing; includes three new frequency cards and a Sacred cardLearn how to incorporate animal totems, colors, sounds, frequencies, vibrations, numbers, and crystals, or do simple card readings
