It all depends on the depth of the wrinkle and level of skin firmness. Wrinkle are much easier to reverse when the skin is still firm, with a healthy amount of elastin. I am now in my mid-forties, and content with the fact that I have been able to reverse every fine line as soon as it began forming on my face. I have never resorted to any type of injectables, lasers or advanced facials. Be well. Be safe. Be beautiful!