Do you have armpit fat? So many of my clients do and report it as being a huge insecurity. That's why I'm sharing a workout for armpit fat and tips to lose fat. First things first, it's impossible to spot reduce fat in one area. So targeting fat loss in specific areas like the armpits, is a common misconception. Fat loss generally occurs throughout the body with a combination of cardio exercise, strength training, and a healthy diet. However, it is possible to target the muscles around and near the armpit area to help improve muscle tone and overall appearance.