(...) Offrons le globe aux enfants, Qu'une journée au moins le globe apprenne la camaraderie, Les enfants prendront de nos mains le globe Ils y planteront des arbres immortels. Nazim Hikmet 53 pays à colorier, didactiques et ludiques depuis 2009 :...

Are student rewards or your treasure box making you go broke? Not anymore! Check out this list of 50 absolutely free student rewards!

Retour à l'illustration en douceur, avec un cahier de coloriages pour les toutis rikikis : cahier découverte sur les couleurs ! Pour Hugo l'escargot, et à télécharger gratuitement , en cliquant sur la vignette... A vos crayolas ! Cliquez sur les pots...

puqles C towel lont fl'e^d:í socks o o cop l-.e r. ; \/ ll I '' ,t: \_/ tata duck showe? cop boot skírt shorts tops sh oes plont toifet rolf po .J :- a t I h. ,t I I scooter dog slide bird i'g _l t - bench boll kite i. I-r \, ond television fornp tje-bock pof ish (.-'! cup of teo plont pot cleane? drínk curTof ns LE ooo al l. urnbrella litter bin toxi trof f ic word en sf gn hondbag rnotorbjke puddle prefpnt Chrístrn trees t, jce-skotes coot PIPE ici cle o oo oo ?\ robin scarf skis hof ly z\

Retour à l'illustration en douceur, avec un cahier de coloriages pour les toutis rikikis : cahier découverte sur les couleurs ! Pour Hugo l'escargot, et à télécharger gratuitement , en cliquant sur la vignette... A vos crayolas ! Cliquez sur les pots...

(...) Offrons le globe aux enfants, Qu'une journée au moins le globe apprenne la camaraderie, Les enfants prendront de nos mains le globe Ils y planteront des arbres immortels. Nazim Hikmet 53 pays à colorier, didactiques et ludiques depuis 2009 :...

Dress up your gear with our kawaii fencing sticker sheet! A perfect blend of sporty charm and cuteness, this vinyl sticker sheet is the ultimate fencing gift for any enthusiast. Elevate your bullet journal or personalize your items with these unique fencer stickers. Unleash the fencing spirit in style! DETAILS: .: These kiss cut stickers come on a premium vinyl waterproof sticker sheet, and are perfect for planning, scrapbooking or even decorating water bottles, glasses, laptops and more! 
 .: Sticker Sheet Size: Approx. 4 inches x 6 inches. .: Listing for 1 sticker sheet = 10 stickers. .: Scratch and fade resistant. .: Original designs by our team! GREAT GIFT IDEA: .: These stickers make a great gift idea for anyone who loves to fence, loves cute designs, or loves to decorate with stickers. They can place it on their water bottle, laptop, or anywhere that could use some fun! .: It also makes a great gift for yourself. NOTE: .: Please note that colors on your screen may vary ever so slightly because of different monitor setups. SHIPPING: .: Once your order is placed, you can expect it to arrive within 14 days. MORE: .: Like what you see? Find more listings in my shop: www.etsy.com/shop/allezmoche .: Follow my shop to stay up to date, as I’m consistently adding new designs. .: Thank you for supporting my small business. .: If you have any questions, please message me, and I’ll get back to you as soon as possible!

(...) Offrons le globe aux enfants, Qu'une journée au moins le globe apprenne la camaraderie, Les enfants prendront de nos mains le globe Ils y planteront des arbres immortels. Nazim Hikmet 53 pays à colorier, didactiques et ludiques depuis 2009 :...

22 coole Sehenswürdigkeiten & Highlights in Venedig: ✓ Markusplatz & Markusdom ✓ Tickets ohne Warten ✓ Geheimtipps ✓ u.v.m.

(...) Offrons le globe aux enfants, Qu'une journée au moins le globe apprenne la camaraderie, Les enfants prendront de nos mains le globe Ils y planteront des arbres immortels. Nazim Hikmet 53 pays à colorier, didactiques et ludiques depuis 2009 :...

(...) Offrons le globe aux enfants, Qu'une journée au moins le globe apprenne la camaraderie, Les enfants prendront de nos mains le globe Ils y planteront des arbres immortels. Nazim Hikmet 53 pays à colorier, didactiques et ludiques depuis 2009 :...

Explore loïc doudou's 175 photos on Flickr!

G H D H S H K B G W E G S S X H X P G F D N G H O N F K F F Z N K P K U B N O I G Q I C B L O Q Q L K I I T P Y I O D D W N K T Z Q X W B K W D I W G N T F M B L E I L U Q M V B A O A N X N B G G L B Y C D D Z H M A T O W L G U A O N R L...

My formula and tips for packing a carry-on bag for a week long trip in cold weather. Hint: It all comes down to the tote.

Can visiting a chiropractor for vertigo help with cervical spondylosis? How can patients cope and improve their situation? Read more here at UCA.

I've taken a bit of time away from blogging because I've been swamped with clients and wanted to spend what free time I have reading. I've come across some very interesting stuff that I believe plays a significant role in hormonal balance that no one is covering so I'll do my best to break it down in to digestible information. Anabolic carbohydrate metabolism When people think of carbohydrate metabolism, they immediately think of glycolysis and maybe even the citric acid cycle. Both of these reactions are catabolic, they are oxidative processes that make ATP through the breakdown of glucose. However, there is another pathway of glucose metabolism called the pentose phosphate pathway that is anabolic in nature. The function of the pentose phosphate pathway is to produce reducing equivalents to power anabolic reactions, to produce ribose 5 phosphate(R5P) for the synthesis of DNA, and to help shuffle carbons between sugars so that they can be utilized again. But why is this important? Let's take a look. Anaerobic glycolysis is the breakdown of glucose in the cytosol of cells. The first step uses ATP to make glucose 6 phosphate(G6P) which can either continue along the pathway of glycolysis to make ATP or be directed through the pentose phosphate pathway to produce reducing equivalents and/or R5P. The path that G6P takes is ultimately dictated by cellular needs. To make this uber-confusing I'll post the steps of both pathways below. It's not really important that you focus on the steps so much as the parallel pathways that glucose metabolism can take based on cellular needs. Depending on cell type, there are different levels of pentose phosphate pathway activity. Cells that are exposed to high levels of oxidative stress, that produce hormones, and that have a high turnover rate tend to have more flux through the pentose phosphate pathway. But why? The 2 phases of the pentose phosphate pathway There are 2 phases of the pentose phosphate pathway, an oxidative phase and a non-oxidative phase, both shown below. The oxidative phase of the pentose phosphate pathway The oxidative phase reduces 2 nicotinamide adenine dinucleuotide phosphates (NADP+) to 2 NADPH, the reduced form. This is important for 2 reasons. First, NADPH is needed to convert oxidized glutathione to its reduced form. Everyone and their mother who is trying to optimize health is likely taking some form of supplement or eating foods that promote glutathione production. Glutathione is known as the master antioxidant as it goes around donating electrons to free radicals before they can react with cellular structures. The problem is, once glutathione does this it's converted to its oxidized form which can no longer donate electrons. In this form, glutathione is essentially worthless until NADPH reduces it back to the active form. This converts NADPH back to NADP+ where the oxidative phase of the pentose phosphate pathway can swing back in and produce more NADPH. For this reason, any cell that is subject to high levels of oxidative stress such as red blood cells and liver cells has a very active pentose phopshate pathway. The figure below illustrates the process by which NADPH reduces oxidized glutathione. Note that selenium is needed in order for glutathione to reduce free radicals and NADPH and riboflavin are needed to reduce oxidized glutathione back to its active form. Without NADPH, glutathione remains inactive, something you most certainly do not want. The pentose phosphate pathway is the primary way in which our cells make NADPH for this purpose. In addition, cells of the immune system used NADPH to kill foreign pathogens through a process called the respiratory burst. A decrease in the ratio of NADPH:NADP+ ratio will compromise the immune system and provide an environment where pathogens can evade killing by phagocytosis. The next reason that the oxidative phase is important is because reducing power is needed for all anabolic processes. This includes the biosynthesis of hormones, so there are high levels of pentose phosphate activity in the adrenal and sex glands. With insufficient reducing power in the form of NADPH, hormonal balance can be thrown out of whack. This includes the adrenal and sex hormones as well as the the thyroid, but for a different reason. Several reversible hormonal conversions are dependent on the ratio of NADPH to NADP+ including: DHEA Androstenediol Androstenedione Testosterone Estrone Estradiol Cortisone Cortisol NADPH causes the conversions to go from left to right while NADP+ causes them to go from right to left. So what does this mean? NADPH will convert androstenedione to testosterone while NADP+ will convert testosterone to androstenedione. In other words, reduced flux through the oxidative arm of the pentose phosphate pathway will negatively impact testosterone levels in men because there will be more NADP+ than NADPH which favors androstenedione over testosterone. I am no expert on women's hormonal issues, but given the fact that estrone is the predominant form of estrogen in postmenopausal women while estradiol is the predominant form in women of reproductive age, I'll go out on a limb and say this conversion is likely detrimental. On the adrenal side of things, reduced flux through the oxidative arm of the pentose phosphate pathway will negatively impact cortisol levels by favoring cortisone production. Since cortisol has greater glucocorticoid activity and cortisone has no mineralocorticoid activity, this can have a pretty significant effect on glucose levels, inflammation, and electrolyte balance. Since these hormonal conversions occur in the endoplasmic reticulum(ER) of cells, the ratio of NADPH:NADP+ within the ER can have a pretty significant effect on hormonal balance. Reduced flux through the pentose phosphate pathway and high levels of oxidative stress are 2 factors that can decrease this ratio leading to poor hormonal balance. With the thyroid, the proposed mechanism by which reduced flux through the oxidative arm of the pentose phosphate pathway may negatively impact hormone production is through a reduction in glutathione function. The thyroid relies on hydrogen peroxide, a free radical, for thyroid hormone synthesis. Without sufficient levels of reduced glutathione to keep this in check, the thyroid can become damaged, inflamed, and thyroid function can become compromised. The non-oxidative phase of the pentose phosphate pathway The non-oxidative arm of the pentose phosphate pathway is also important, especially in tissues with high rates of cell turnover. The non-oxidative arm of the pentose phosphate pathway essentially interconverts sugars in to different forms. One of those sugars, R5P, is necessary for DNA production. Cells with high turnover rates such as epithelial cells in the gut are dependent on sufficient flux through the non-oxidative arm to produce enough DNA for replication. The non-oxidative arm also gives the pentose phosphate pathway flexibility. By interconverting sugars, the non-oxidative arm can create sugars that can re-enter glycolysis to generate pyruvate or feed back in to the oxidative arm to create more NADPH. The non-oxidative arm allows the pentose phosphate pathway and glycolytic pathways to work synergistically to meet cell needs. There are essentially 4 modes of pentose phosphate pathway activity that can be used to increase energy levels, increase reducing power, provide building blocks for DNA, or a combination of these functions. The yield of each mode is: Mode 1-6 G6P makes 5 R5P Mode 2-1 G6P makes 1 R5P and 2 NADPH Mode 3 -1 G6P makes 12 NADPH Mode 4-3 G6P make 6 NADPH, 8 ATP, & 5 pyruvate and NADH which can be used to create more ATP As you can see, carbohydrate metabolism is a lot more than simply breaking down glucose to use for energy. Carbohydrate metabolism also has anabolic effects via the pentose phosphate pathway. Decreased flux through the pentose phosphate pathway can increase oxidative stress and negatively impact hormonal balance and cellular reproduction. There is compelling scientific evidence that altered flux through the pentose phosphate pathway may be at the root of adrenal dysfunction, increased inflammation, and some gut pathologies including SIBO. In addition, many metabolic consequences of Type 2 diabetes can alter flux through the pentose phosphate pathway and there are many blood markers we see in Type 2 diabetes that indicate this. If there is enough demand I may pull some of that stuff out, so read, like, and share.

(...) Offrons le globe aux enfants, Qu'une journée au moins le globe apprenne la camaraderie, Les enfants prendront de nos mains le globe Ils y planteront des arbres immortels. Nazim Hikmet 53 pays à colorier, didactiques et ludiques depuis 2009 :...

In my quest to find a flipbook template that I can use to insert information for my class, I came up with nothing that was free... I didn't think I should pay for a template and then still complete with the relevant information. Therefore, I made my own! It is simple. This means, when you download it, you can fully customize it to suit your needs. It comes in color and black and white. PLEASE NOTE: the MLA Formatting resource is not included here. It is shown as an example of how the product can be used. Please Enjoy this Freebie!

Read the theory behind pronouns, know why pictures of pronouns can make it easier to learn them, and use a collection of pictures for free.

(...) Offrons le globe aux enfants, Qu'une journée au moins le globe apprenne la camaraderie, Les enfants prendront de nos mains le globe Ils y planteront des arbres immortels. Nazim Hikmet 53 pays à colorier, didactiques et ludiques depuis 2009 :...

Get more from ɴᴏ sᴛʏʟᴇ x ᴡ ᴏ ᴏ ᴅ ʟ ᴀ ɴ ᴅ on Patreon

(...) Offrons le globe aux enfants, Qu'une journée au moins le globe apprenne la camaraderie, Les enfants prendront de nos mains le globe Ils y planteront des arbres immortels. Nazim Hikmet 53 pays à colorier, didactiques et ludiques depuis 2009 :...

*Teacher of Kindergarten *Sharer of classroom tips and resources *Creator of lessons for the culturally relevant classroom *Lover of all things Home*

Get more from dreamgirl on Patreon

3 i t a l i a n o CETEM ortografia,morfologia,sintassi,lessico ,produzione e giochi linguistici

G U I D A D I D A T T I C A Rosal ba Pan i z · L u i s a P a v e s i · L o r e d a n a F l o r i o Colore Segno Attività espressive con AUDIO CD me v o l u G U I D A D I D A T T I C A Rosal ba Pan i z · L u i s a P a v e s i · L o r e d a n a F l o r i o Si ringraziano i bambini e le insegnanti della Scuola dell’Infanzia Paritaria Enfants Paradise di Torino. Si ringraziano i bambini e l’insegnante Giovanna Ortolani per le attività laboratoriali. me v o l u

Here are some of the most important lessons I picked up in my first year of sewing. This isn't an exhaustive list, but these are some of the things that I struggled with or that confused me at first. These tips and tricks should help a beginner who is just learning to sew.

Share this with crafty friends.... Pinterest Facebook TwitterEvery child deserves a super hero cape to live out their dreams and the good news is that now you don’t have to buy one from a high priced children’s store. Today I’m sharing a no sew super hero cape that everyone can easily find the supplies to […]