Pathogenic mitochondrial DNA (mtDNA) mutations leading to mitochondrial dysfunction can cause a variety of chronic diseases in central nervous system (CNS). However, the role of mtDNA mutations in sporadic Creutzfeldt–Jakob disease (sCJD) has still been unknown. In this study, we comparatively analyzed complete mtDNA sequences of 31 Chinese sCJD patients and 32 controls. Using MITOMASTER and PhyloTree, we characterized 520 variants in sCJD patients and 507 variants in control by haplogroup and allele frequencies. We classified the mtDNAs into 40 sub-haplogroups of 5 haplogroups, most of them being Asian-specific haplogroups. Haplogroup U, an European-specific haplogroups mtDNA, was found only in sCJD. The analysis to control region (CR) revealed a 31% increase in the frequency of mtDNA CR mutations in sCJD versus controls. In functional elements of the mtDNA CR, six CR mutations were in conserved sequence blocks I (CSBI) in sCJD, while only one in control (P<0.05). More mutants in transfer ribonucleic acid-Leu (tRNA-Leu) were detected in sCJD. The frequencies of two synonymous amino-acid changes, m.11467A>G, p.(=) in NADH dehydrogenase subunit 4 (ND4) and m.12372G>A, p.(=) in NADH dehydrogenase subunit 5 (ND5), in sCJD patients were higher than that of controls. Our study, for the first time, screened the variations of mtDNA of Chinese sCJD patients and identified some potential disease-related mutations for further investigations.
In the entrancing expanse of Bumbling in Foxholes C2, one's gaze is immediately drawn to the lush cerulean that washes over the canvas in waves of tranquility. This piece seamlessly marries the serene azure with undercurrents of a delicate alabaster, crafting a composition ripe with visual harmony. Amidst these cooler tones, the sporadic emergence of a vibrant, rosy magenta beckons the eye, evoking a sense of artistic innovation. The shifting textures within the artwork suggest a dynamic landscape of color, sculpted not by tools of traditional mark-making but through an unconventional dance of pigment upon canvas.Contemplating Bumbling in Foxholes C2 within an assembly, one discovers a compelling narrative when paired with neighboring scales such as C3 and C4. Such a collection might hang with a grace that fills the room with a rhythmic flow, uniting the observer with the larger color field of the original work. The suggestion of larger, fine art prints is alluring, inviting one to immerse in the detailed exploration of form that only a grander scale can offer, further enhancing the room's ambiance with its museum-quality presence.Envision this canvas as the heart of a minimalist or contemporary styled chamber, where its soothing blues and pops of pink draw together elements of design within an organic or sleek interior. Bumbling in Foxholes C2's melody of hues creates a visual poem, offering a transformative backdrop to spaces seeking vibrant art that sings with bright, harmonious undertones. The essence of Bumbling in Foxholes C2 lies not just in its color but in the evocative stillness it imparts, a quiet recollection of abstract beauty nestled within an art lover's personal sanctuary.
Published in 1494 in Basel, The Ship of Fools was soon translated into every major European language. It provoked a vast number of imitations and remained steadily in print through the eighteenth century (with sporadic reprints after that). It still possesses an enormous vigor and vitality.The book owes its long life to an imagination, wit, and humor rich with insights into human nature, yet neither bitter nor namby pamby. Its commentary on the boasting, pedantry, false learning, gambling, gluttony, medical folly, adultery, greed, envy, hatred, pride and other failings that mark humanity are sharp and telling, and, sadly, as relevant today as they were 450 years ago.This translation by Professor Edwin H. Zeydel is the only accurate English translation ever published. (Barclay's version is really a pastiche written in imitation of Brant.) The form Professor Zeydel uses is verse, like the original, and he even retains the original rhyme scheme and meter. The achievement is remarkable, for it captures all the charm and movement of the original German while sacrificing nothing to readability and fluidity.Published now with the 114 original Renaissance woodcuts and with Professor Zeydel's annotations, a biography of Brant, a publishing history, and a survey of the work's influence, this will unquestionably remain the definitive edition of The Ship of Fools in English. The illustrations are part of Dover's Pictorial Archive Series and may be used by commercial artists free of charge. satirical allegories; german verse; definitive editions; medieval german satire; biographical information; provocative literature; human nature; religious allegories; woodcut illustrations; religious figures; social commentary; morality tales; sin; gluttony; gambling; adultery; the ills of humanity; rhyme scheme; metered writing; humanism; christianity; religion; church; imaginative stories; pictorial archives; 15th century literature; allegorical classic; woodcuts; Brant; Narrenschiff
An invigorating name inspired by the words 'sporadic', 'sport' or 'go'. Possible uses: A discounts site. A travel brand. An app developer. A sports brand.
"That's' not a lot." A man told me cutting expenses by $180 is not enough to go through 5 mintutes of work. "It's a hassle." I told him, "Let me know if you find another way, other than drug-dealing, to create that much money in 5 minutes of work." He's...
Picture this: you've spent countless hours meticulously crafting your blog, pouring your heart and soul into every word, only to hit publish and... crickets.
You never know where or when the occasion to use sporadic will pop up, but when it does, sporadic is the perfect choice to describe something that happens randomly or irregularly, often in scattered
I’m back! This hobby was too fun to give up on just because it wasn’t relevant to my career anymore. Sporadic updates from now on, though. Sources: Wiktionary & Online Etymology Dictionary
You never know where or when the occasion to use sporadic will pop up, but when it does, sporadic is the perfect choice to describe something that happens randomly or irregularly, often in scattered
The Paradiddle. The most popular drum rudiment. So dramatic! Could be the flam actually. I’ll never look at the paradiddle in the same way, after a student asked a sporadic question “who created the paradiddle?”. I replied quickly with “Jerry Paraddidle”. After some chuckles at the name and then the rest of the lesson passing, […]
The twenty-fourth chronicle of Matthew Bartholomew. In 1360 Edward III issues a call to arms, as sporadic attacks by the French threaten to turn into a full-blown invasion. In Cambridge, fear of the enemy is magnified by the belief that foreign agents are lurking in the area. Tension runs ever higher as rumours and ignorance fan the flames of suspicion amid preparations for war. And then the first murder occurs - of a French scholar living in the town. At Michaelhouse, Brother Michael is now Master, but his reach of power in the University is under threat by the election of a new Chancellor and his cohort of dubious advisors. Soon, the Colleges begin to squabble amongst themselves, as well as with the town that never wanted a University in the first place. Amidst this atmosphere of swelling distrust, physician Matthew Bartholomew is called upon to investigate mysterious deaths in a nearby hospital. He quickly realises that there is something odd about the inmates and their keepers - something dark and deadly, which seems to be connected to the growing number of murders in the town. Pressure mounts as the University and the town clamour for answers, leading Bartholomew and Michael in a frantic quest for a solution before the powder-keg of animosity in Cambridge is ignited. 'A first-rate treat for mystery lovers' (Historical Novels Review) 'Susanna Gregory has an extraordinary ability to conjure up a strong sense of time and place' (Choice)
Text you can send to someone who’s breadcrumbing you. Breadcrumbing in dating refers to when someone gives just enough attention and communication to keep another person interested, without...
Understanding America's favorite democratic socialist's sporadic pragmatism.
In the current issue of JNNP, Varges and colleagues have published a randomized control trial (RCT) phase II comparing doxycycline versus placebo in early sporadic Creutzfeldt-Jakob disease (sCJD). CJD is a fatal and heterogeneous neurodegenerative disease caused by the misfolding and aggregation of prions. Clinically, CJD is characterized by rapidly progressive cognitive impairment associated [...]Read More...
It is a sporadic case to hear people complain or ask what to do if a Cockroach bite eye, but then again, what in this world is impossible, right...
Propagation Prediction Websites for HF and VHF bands
Easiest Holiday Fudge You need: 1 1/2 c semi sweet chocolate chips 1 1/2 c milk chocolate chips 1 can (14 oz.) sweetened condensed milk (not evaporated) 1 1/2 c chopped walnuts 2 tsp vanilla Line a 8 inch square pan with wax paper, or foil. In a double boiler, melt chocolate chips, add milk and stir constantly until incorporated. Remove from heat. Stir in vanilla and walnuts. While still hot, pour immediately into lined pan. Place into refrigerator for at least 2 hours to completely cool and set recipe. You might have to go longer. When firm, remove from wax paper or foil, and cut into 8 rows by 8 rows for 1" pieces. Variations to this recipe can be any 1 1/2 c chopped nuts you prefer (ex: almonds, pistachios, hazelnuts, or cashews). Or you can make this very festive by using crushing up candy canes instead of nuts. I have found this recipe, if I watch sales and use coupons during holiday season, is very cheap and easy to make! Chocolate chips are frequently on sale! This makes this fudge, for me, a perfect addition to holiday gift plates! It actually is Frugal, in that the recipe is so inexpensive, and the candy so rich, it goes a long way- it makes for a fantastic gift without high cost! Allowing me to share the season without a huge cut in my budget. :)
Sporadic gunshots rented the air as Governor Ahmed Ododo of Kogi state departed the residence of Yahaya Bello, his predecessor, on Wednesday, April 17.
This quote has been my December, January, and seemingly the start of February. Writing much of anything has been sporadic and unfocused. I guess between journaling, creative writing projects, and t…
So, you're seeing someone and all you're getting is vague, sporadic messages? Could it be... Here are 6 signs they're breadcrumbing you..
Explore Dempster Lane's 740 photos on Flickr!
Mobile network operator EE (BT) has today become only the second such provider after VOXI (Vodafone) to launch a low-cost social tariff - EE Basics - for mobile
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Sporadic describes the distribution of something across space or time that is not frequent enough to fill an area or period, often in scattered instances or isolated outbursts (as in 'sporadic
