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WNT Signaling
This publication delves into new and exciting research in bioinformatics, healthcare, and biology. It’s a space to document discoveries, ask questions, and connect ideas across disciplines. Follow along for thoughtful insights and tutorials at the forefront of the life sciences.
[IMG] This volume contains information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and...
The Hedgehog pathway is responsible for regulating and coordinating cellular growth and development in the embryo. Under specific time or position-dependent stimuli, cells secrete the hedgehog family ligands (sonic, desert, and indian), whose binding allo
A signal molecule binds to a receptor, activates a signal transduction pathway, and ultimately sparks a reaction in the receiving cell.
ヒトプロテインキナーゼについて：プロテインキナーゼは細胞機能の重要な調節因子です。
Learn more about Akt and the integral role it plays in mediating signals for cell growth, survival, cell cycle progression, differentiation, and glucose metabolism.
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Akt Signaling
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Researchers have long wondered how developing tissues and organs are signaled to stop growing upon reaching maturity. The Hippo (or SWH) signaling pathway has been shown to be responsible for controlling organ growth and size by limiting cell proliferatio
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
The mTOR signaling pathway regulates cell growth, metabolism, and survival in response to nutrients and growth factors.
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