Our board-certified peripheral artery disease doctors specialize in providing the best in care for patients suffering from PAD in Phoenix, AZ. Call today!
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Aging is the greatest non-modifiable risk factor for most diseases, including cardiovascular diseases (CVD), which remain the leading cause of mortality worldwide. Robust evidence indicates that CVD are a strong determinant for reduced brain health and all-cause dementia with advancing age. CVD are also closely linked with peripheral and cerebral vascular dysfunction, common contributors to the development and progression of all types of dementia, that are largely driven by excessive levels of oxidative stress (e.g., reactive oxygen species [ROS]). Emerging evidence suggests that several fundamental aging mechanisms (e.g., “hallmarks” of aging), including chronic low-grade inflammation, mitochondrial dysfunction, cellular senescence and deregulated nutrient sensing contribute to excessive ROS production and are common to both peripheral and cerebral vascular dysfunction. Therefore, targeting these mechanisms to reduce ROS-related oxidative stress and improve peripheral and/or cerebral vascular function may be a promising strategy to reduce dementia risk with aging. Investigating how certain lifestyle strategies (e.g., aerobic exercise and diet modulation) and/or select pharmacological agents (natural and synthetic) intersect with aging “hallmarks” to promote peripheral and/or cerebral vascular health represent a viable option for reducing dementia risk with aging. Therefore, the primary purpose of this review is to explore mechanistic links among peripheral vascular dysfunction, cerebral vascular dysfunction, and reduced brain health with aging. Such insight and assessments of non-invasive measures of peripheral and cerebral vascular health with aging might provide a new approach for assessing dementia risk in older adults.
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In our many years of practicing medicine, we’ve found that there are two medical terms that almost always confuse our patients. The two terms are peripheral artery disease (PAD) and peripheral vascular disease (PVD). We do understand the confusion. These two terms sound similar, as if they’re describing the same disease or medical condition. It’s […]
DEAR MAYO CLINIC: My mother, 67, was recently diagnosed with peripheral artery disease. She has been having leg pain and other symptoms for many months. She was prescribed medication but her doctor said she may need surgery. What would that involve? Are there any other treatment choices? ANSWER: In people who have peripheral artery disease, […]
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Since 2005, Western Vascular has offered the best in vein and vascular care to patients in Phoenix, Arizona. Call to schedule an appointment today!
Association for Vascular Access.
Our board-certified vascular surgeons provide comprehensive care for patients suffering from carotid artery disease in Phoenix, AZ. Call today!
Vasculitis is an umbrella term that describes subtypes of blood vessel inflammation in different parts of the body. Learn the role of antibodies.
Peripheral artery disease (PAD) is obstruction of the arterial lumen resulting in decreased blood flow to the distal limbs. This can be a result of atherosclerosis or thrombosis.
This common blood flow condition can cause leg pain when walking. Lifestyle changes and medicines can help, but sometimes surgery is needed.
Study Urinary System flashcards taken from chapter 26 of the book Fundamentals of Anatomy & Physiology.
Heres Why Your Legs Cramp Up at Ni
Blood flow to the legs (and sometimes the arms) can be reduced when their arteries are affected by peripheral arterial disease (PAD). Narrowing of the periphera
Peripheral artery disease (PAD) is a condition of the blood vessels that supply the legs and feet. It occurs due to narrowing of the arteries in the legs. This causes decreased blood flow, which can injure
Our vascular center in Phoenix, AZ provides vein and vascular diagnostic tests to diagnose and assist our experts to find the best treatment. Call today!
