Formerly lots of French Revolution content! I'm out of energy for posting much but if that's what you're looking for, check the tags for Marat, Desmoulins, etc. (If you're here because I followed your MDZS account, my Untamed/MDZS account is @inappropriatewenning) Bits of Les Misérables, natural history, art, odds and ends. Occasional succulents. Kids. Spinning, weaving, felting, polymer clay. Stuff. Please shoot me a message if you see anything here that needs correction.
Formerly lots of French Revolution content! I'm out of energy for posting much but if that's what you're looking for, check the tags for Marat, Desmoulins, etc. (If you're here because I followed your MDZS account, my Untamed/MDZS account is @inappropriatewenning) Bits of Les Misérables, natural history, art, odds and ends. Occasional succulents. Kids. Spinning, weaving, felting, polymer clay. Stuff. Please shoot me a message if you see anything here that needs correction.
Historical fiction author Kelly Gardiner shares some of the wonderful free resources that writers can use to make the most out of their research time.
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Read 14 reviews from the world’s largest community for readers. "Proper management of the work lives of human beings, of the way in which they earn their l…
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In order to build a truly Agile business, you need the right tools to help: you need a powerful work OS. In this article, discover 4 best work OS.
In this groundbreaking first volume of SAGE's Evaluation in Practice Series, best-selling author Donna M. Mertens explores the meaning of mixed methods evaluation, its evolution over the last few decades, and the dominant philosophical frameworks that are influencing thought and practice in the field today. Four chapters explore evaluation of the effectiveness of interventions, development of instruments, systematic reviews, and policy evaluations, while an additional chapter covers evaluation a
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer associated with advanced age and immunosuppression. Over the past decade, an association has been discovered between MCC and either integration of the Merkel cell polyomavirus, which likely drives tumorigenesis, or somatic mutations owing to ultraviolet-induced DNA damage. Both virus-positive and virus-negative MCCs are immunogenic, and inhibition of the programmed cell death protein 1 (PD-1)–programmed cell death 1 ligand 1 (PD-L1) immune checkpoint has proved to be highly effective in treating patients with metastatic MCC; however, not all patients have a durable response to immunotherapy. Despite these rapid advances in the understanding and management of patients with MCC, many basic, translational and clinical research questions remain unanswered. In March 2018, an International Workshop on Merkel Cell Carcinoma Research was held at the US National Cancer Institute, at which academic, government and industry experts met to identify the highest-priority research questions. Here, we review the biology and treatment of MCC and report the consensus-based recommendations agreed upon during the workshop. Merkel cell carcinoma (MCC) is a rare and aggressive form of nonmelanoma skin cancer. The availability of immune checkpoint inhibition has improved the outcomes of a subset of patients with MCC, although many unmet needs continue to exist. In this Consensus Statement, the authors summarize developments in our understanding of MCC while also providing consensus recommendations for future research.
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"Strategic" research is a confusing label. By considering research "scope", we can more effectively plan to strategic UXR impact.
