DISCLAIMER: I am not a medical doctor. Please do not make any decisions without speaking to your healthcare provider. I will not be held liable for any decisions you make from reading this blog. This blog is to not offer medical advice. I’ll never forget when I found out I had MTHFR. We just had […]
A new finding of an inherited gene mutation, the MTHFR Mutation, has been linked to conceiving troubles in women. Here are some things to know about it.
MTHFR mutations can impact folate metabolism. But there is confusion whether we should eat more or less folate. This short article explains it.
Dr. Doni, naturopathic doctor and midwife, explains how MTHFR increases risk of miscarriage and how to get the right kind of support for your pregnancy.
Have you heard of MTHFR? As an expecting mother, or someone considering pregnancy, knowing your MTHFR status important for both... Read More
While MTHFR gene mutations can inhibit the conversion of folate you eat (dihydrofolate) into the active folate (5-MTHF), is it still vitally important to consume as much natural folate as you can through your diet. Is it important to remember, a mutation in the MTHFR gene simply means a reduction in function, not that it … Top 20 Folate Containing Foods Read More »
Testing positive for a mutated MTHFR gene might impact your pregnancy and your baby-to-be. Here’s a look at the risk factors and treatment options.
Do you suffer from miscarriage and or infertility? MTHFR gene mutations can cause these problems but there are many other gene mutations that can be worse..
Living with an MTHFR Gene Mutation : A Guide from a 30 Year MTHFR Veteran Browse Categories B-12 COVID-19 Deficiencies Fertility / Pregnancy / Women's Health Health Issues Kid's Health Mental Health Methylfolate Facts MTHFR Genetics News Resources Staying Healthy Super-B-Complex The terms MTHFR, methylat
What to do 3 months before you get pregnant if you or your partner has the MTHFR gene mutation.
A "defect" in your genes can influence how well you metabolize nutrients. The MTHFR Mutation is a common and potentially dangerous defect with many symptoms
Many Americans may be MTHFR deficient and unaware of the same. MTHFR gene mutations can lead to nutritional deficiencies, fatigue, mental health issues,
Two of the most studied genetic defects are MTHFR C677T and MTHFR A1298C. This article attempts to clarify what they are, in a way you can understand.
MTHFR mutations can impact folate metabolism. But there is confusion whether we should eat more or less folate. This short article explains it.
I have an MTHFR mutation: what do I do now? B-12 COVID-19 Deficiencies Fertility / Pregnancy / Women's Health Health Issues Kid's Health Mental Health Methylfolate Facts MTHFR Genetics News Resources Staying Healthy Super-B-Complex I have an MTHFR mutation: what do I do now? If you’re reading this article, i
Have you been diagnosed with a MTHFR gene mutation? If so, don't be discouraged. You can still enjoy vibrant health. You just have to learn how to work with your MTHFR genes to detox properly despite them. Click here to learn how.
There is a link between MTHFR and infertility, and it can be worsened by stress. But certain supplements and diet changes may help.
What supplements to take when pregnant with MTHFR? Methylfolate and Pregnancy Browse Categories B-12 COVID-19 Deficiencies Fertility / Pregnancy / Women's Health Health Issues Kid's Health Mental Health Methylfolate Facts MTHFR Genetics News Resources Staying Healthy Super-B-Complex Methylfolate is important d
MTHFR gene mutations affect 30-50% of our population, although most of us don't know whether or not we have it. So what is MTHFR, exactly?
MTHFR affects a ton of people! This article we'll touch base on the MTHFR Gene Mutation, the importance of MTHFR Testing and treatment, MTHFR and autism.
DISCLAIMER: I am not a medical doctor. Please do not make any decisions without speaking to your healthcare provider. I will not be held liable for any decisions you make from reading this blog. This blog is to not offer medical advice. I’ll never forget when I found out I had MTHFR. We just had […]
An MTHFR gene mutation affects the body's ability to use folic acid or folate & increases risk of disease. Learn how to know if you have it and what to do.
MTHFR gene mutations affect 30-50% of our population, although most of us don't know whether or not we have it. So what is MTHFR, exactly?
Getting pregnant with mthfr gene mutations easy when you know what you need to do to be successful. MTHFR pregnancy is all about being prepared.
The MTHFR mutation is very common. If you have it, it may change your nutrient requirements and needs. Here's everything you need to know and 6 things to do in response.
Continue reading and learn all about the MTHFR gene mutation. Plus discover some of the surprising conditions which have been linked to this common mutation
What lifestyle changes are recommended for people with MTHFR mutations? What are the best foods for people with MTHFR? In this post, we explore what experts have to say on the subject.
We hear a lot about vitamin B9 (aka folic acid or folate) for fertility and pregnancy, and it’s for a good reason. It's necessary for DNA synthesis, and therefore is considered key for proper egg development and ovarian function, as well as embryo and fetal growth. In fact, a budding embry
UPDATE POST OF MTHFR BLOG Do you have a genetic defect in the MTHFR gene?? Maybe you've have a family history of heart attack or stroke... maybe you've suffered through multiple miscarriages. Or maybe you struggle with chronic migraine headaches or irritible bowel syndrome or depression. Perhaps your child or a sibling has autism. What do all these things have in common? Well, these are just some of the conditions liked to a faulty enzyme called MTHFR. What's up with MTHFR? MTHFR stands for methyl-tetrahydrofolate reductase, an enzyme that is responsible for the process of methylation in every cell in your body. MTHFR is a common genetic variant that causes this key enzyme in the body to function at a lower than normal rate. This can lead to a variety of medical problems. Although there are over fifty known MTHFR variants, the two primary ones are called C677T and A1298. Your doctor can order a blood test to determine if you have these genetic variants. Better yet, you can order a complete genetic profile yourself through 23andMe. What's the big deal about methylation? Methylation is a core process that occurs in all cells to help your body make biochemical conversions. When people with genetic mutations is MTHFR are exposed to toxins, they have a harder time getting rid of them which can cause some very serious illnesses. The methylation process is responsible for: Cellular Repair: synthesis of nucleic acids, production & repair of DNA & mRNA Detoxification and Neurotransmistter Production: interconversion of amino acids Healthy Immune System Function: formation & maturation of red blood cells, white blood cells & platelet production The 677T variant is most commonly associated with early heart disease and stroke and the 1298C variant with a variety chronic illnesses, but either anomaly can cause a wide variety of health problems. The MTHFR anomaly is reported out as heterozygous or homozygous. If you are heterozygous that means you have one affected gene and one normal gene. Your enzyme activity will run at about 60% efficiency compared to a normal. If you are homozygous or have 2 abnormal copies, then enzyme efficiency drops down to 10% to 20% of normal, which can be very serious. The worst combination is 677T/1298C in which you are heterozygous to both anomalies. Many chronic illnesses are linked to this anomaly. Fibromyalgia, irritable bowel syndrome, migraines, chemical sensitivity, frequent miscarriage and frequent blood clots are all conditions associated with MTHFR anomaly. For a great diagram of more methylation related health problems, check this out: MTHFR Related Health Problems Glutathione is the body's primary antioxidant and detoxifier. One of the ways that MTHFR gene mutation can make you susceptible to illness is by lowering your ability to make glutathione. People with MTHFR anomalies usually have low glutathione, which makes them more susceptible to stress and less tolerant to toxic exposures. Accumulation of toxins in the body and increased oxidative stress, which also leads to premature aging. Some conditions that may be associated with MTHFR gene mutations Autism Addictions: smoking, drugs, alcohol Down’s syndrome Frequent miscarriages Male & female infertility Pulmonary embolism and other blood clots Depression & anxiety Schizophrenia Bipolar disorder Fibromyalgia Chronic Fatigue Syndrome Chemical Sensitivity Parkinson’s disease Irritable Bowel Syndrome Stroke Spina bifida Migraines Hyperhomocysteinemia Breast cancer Atherosclerosis Alzheimer’s Multiple Sclerosis Myocardial Infarction (Heart Attack) Methotrexate Toxicity Nitrous Oxide Toxicity Treatment for MTHFR Fortunately, you can easily be tested for the MTHFR mutation. If you find out that you have one or more of the gene mutations, you can supplement with methyl-folate and methyl B12, the active forms of these B vitamins. You can also supplement with liposomal or acetyl-glutathione, the end product of the pathway. Glutathione is poorly absorbed so either the liposomal form or a precursor, called n-acetylcysteine (NAC) may be used. Some of my favorites are Thorne Research Methyl Guard Plus and 5-MTHF 1mg and 5mg. There are prescription medicines, that also contain methyl-folate: Deplin, MetanX, CerefolinNAC are a few. Methyl B12 can also be given as shots, nasal sprays, and sublingually. The intramuscular shots are by far the most effective method and must be prescribed by your physician. The choice of nutrients will vary from patient to patient and should be done under a doctor's supervision. There is a bell-shaped optimal curve so you may not feel well with too much or too little of the appropriate supplements. Other B vitamins, such as riboflavin and vitamin B6 also play an important role. As you may have surmised, this can be quite complex and I suggest you find a functional medicine trained physician to help you sort through your needs for the different nutrients if you have a chronic health condition related to the gene mutations. It is not uncommon for patients with these genetic polymorphism's to be very sensitive to supplementation. Patients who I recommend screen for MTHFR mutations: Pre-conception care: test both man and woman Mental dysfunction including but not limited to depression, anxiety, irritability, mood swings, schizophrenia, bipolar Infants and children of parents with MTHFR mutations Family members related to someone with MTHFR mutations Elevated folate (not processing to active 5-MTHF due to inability to methylate) Elevated homocysteine (due to low active 5-MTHF and methylcobalamin) Elevated s-adenosylhomocysteine (due to low active 5-MTHF and methylcobalamin) Elevated serum cobalamin (due to inability to methylate cyanocobalamin to methylcobalamin) Elevated methylmalonic acid (due to methylcobalamin deficiency) Patients with syndromes: IBS, Chemical sensitivity, Fibromyalgia, Down Syndrome, Chronic fatigue syndrome Neurological disorders: Multiple sclerosis, Autism, Alzheimer’s, Epilepsy, Parkinson’s to name a few Cancer: family history of cancer or undergoing cancer treatment Cervical dysplasia Infertility Cardiovascular risk: family history of strokes, embolisms, heart attacks, clots, essential hypertension Birth defects: cleft palate, tetralogy of Fallot, spinal bifida, midline defects Drug sensitivities: methotrexate, anti-epileptics, nitrous oxide, anesthesia If you are interested in knowing more about your genes, the 23andme gene test will be the best $99 investment you've ever spent ! Check out Health Tips for Dealing with MTHFR Gene Mutations... Want more great content like this? Sign up for my FREE Newsletter here! For more reading Holistic Primary Care Genetics Home Reference Molecular Biology of MTHFR Genetics of Homocysteine Metabolism Homocysteine and MTHFR mutation 23andMe Gene Test
In line with our current focus on MTHFR in preconception, our founder and MTHFR expert Carolyn Ledowsky has been busy creating and hosting our FREE 10-day email course: ‘10 Days to a Healthy Pregnancy with MTHFR‘. In the course you will be sent one email per day for 10 days, walking you through the 10 … Join our FREE 10-Day ‘MTHFR in Preconception’ Email Course! Read More »
Dr. Doni outlines 8 steps for ensuring a healthy methylation cycle and explains how taking them can optimize your overall health even at the most stressful
Certain mutations of the MTHFR gene may be associated with health problems and complications in pregnancy. Here’s what you need to know.
Women all over the world get folic acid supplements in early pregnancy to prevent birth defects. But are they getting the right forms of the vitamin they need?
Testing Your Children for MTHFR: The What, When, Why, and How Browse Categories B-12 COVID-19 Deficiencies Fertility / Pregnancy / Women's Health Health Issues Kid's Health Mental Health Methylfolate Facts MTHFR Genetics News Resources Staying Healthy Super-B-Complex MTHFR gene mutation, Methylfolate deficienc
Many women with MTHFR experience excessive mood swings and may experience other symptoms related to fluctuations in hormone levels.
MTHFR affects a ton of people! This article we'll touch base on the MTHFR Gene Mutation, the importance of MTHFR Testing and treatment, MTHFR and autism.
Having SNP In the MTHFR gene or the methylation pathway can contribute to SIBO. But what is the connection between MTHFR and SIBO?
