Rhyme-Away Story | LoveToTeach.org
Hedy Lamarr by Clarence Sinclair Bull, 1938.
Chase The Time Away With Caturday (40 Cat Memes) - World's largest collection of cat memes and other animals
Handmade oil painting reproduction from any famous artist - Pierre-Auguste Cot Springtime 1873 - Medium: Oil on Canvas - Original dimensions: 213.4x127 cm (84x50 in) - Made to order - Free shipping, rolled in a tube Each painting is custom made and won't ship until it gets your approval. Classic paintings simply take your breath away! They have a unique theme that makes it to standout in this crowded field. Art-lovers now have the unique opportunity to own each of these paintings as a handmade oil painting reproduction from any famous artist produced by our extremely skilled artist at NamPhuongArt gallery. Our artist reproduces classic paintings by hand, using only the quality oil paints on canvas SIZE Custom size is available PROCESSING TIME The process to make a painting takes between 3-4 weeks because we use oil paint. Oil need time to get dry in fresh air as the paint is oil based but sometimes We have overbooking so it takes a little more. If this happens I would send you an email to inform you before starting the work. Prior to shipping the painting we will send you a digital photo for your approval. This is your chance to suggest any changes and comment the painting. PACKING - Only painting: Rolled in 6 cm reinforced tube made specifically for the paintings. No extra cost. - Ready to hang: Fourth layered cardboard box. It's the safest (and expensive) way possible and the painting arrives brand new. Plus extra cost. Please contact us for more information Shipping made by the UPS Expedited to many places in the world. Transits time 3-5 business days shipping worldwide.
I've taken a bit of time away from blogging because I've been swamped with clients and wanted to spend what free time I have reading. I've come across some very interesting stuff that I believe plays a significant role in hormonal balance that no one is covering so I'll do my best to break it down in to digestible information. Anabolic carbohydrate metabolism When people think of carbohydrate metabolism, they immediately think of glycolysis and maybe even the citric acid cycle. Both of these reactions are catabolic, they are oxidative processes that make ATP through the breakdown of glucose. However, there is another pathway of glucose metabolism called the pentose phosphate pathway that is anabolic in nature. The function of the pentose phosphate pathway is to produce reducing equivalents to power anabolic reactions, to produce ribose 5 phosphate(R5P) for the synthesis of DNA, and to help shuffle carbons between sugars so that they can be utilized again. But why is this important? Let's take a look. Anaerobic glycolysis is the breakdown of glucose in the cytosol of cells. The first step uses ATP to make glucose 6 phosphate(G6P) which can either continue along the pathway of glycolysis to make ATP or be directed through the pentose phosphate pathway to produce reducing equivalents and/or R5P. The path that G6P takes is ultimately dictated by cellular needs. To make this uber-confusing I'll post the steps of both pathways below. It's not really important that you focus on the steps so much as the parallel pathways that glucose metabolism can take based on cellular needs. Depending on cell type, there are different levels of pentose phosphate pathway activity. Cells that are exposed to high levels of oxidative stress, that produce hormones, and that have a high turnover rate tend to have more flux through the pentose phosphate pathway. But why? The 2 phases of the pentose phosphate pathway There are 2 phases of the pentose phosphate pathway, an oxidative phase and a non-oxidative phase, both shown below. The oxidative phase of the pentose phosphate pathway The oxidative phase reduces 2 nicotinamide adenine dinucleuotide phosphates (NADP+) to 2 NADPH, the reduced form. This is important for 2 reasons. First, NADPH is needed to convert oxidized glutathione to its reduced form. Everyone and their mother who is trying to optimize health is likely taking some form of supplement or eating foods that promote glutathione production. Glutathione is known as the master antioxidant as it goes around donating electrons to free radicals before they can react with cellular structures. The problem is, once glutathione does this it's converted to its oxidized form which can no longer donate electrons. In this form, glutathione is essentially worthless until NADPH reduces it back to the active form. This converts NADPH back to NADP+ where the oxidative phase of the pentose phosphate pathway can swing back in and produce more NADPH. For this reason, any cell that is subject to high levels of oxidative stress such as red blood cells and liver cells has a very active pentose phopshate pathway. The figure below illustrates the process by which NADPH reduces oxidized glutathione. Note that selenium is needed in order for glutathione to reduce free radicals and NADPH and riboflavin are needed to reduce oxidized glutathione back to its active form. Without NADPH, glutathione remains inactive, something you most certainly do not want. The pentose phosphate pathway is the primary way in which our cells make NADPH for this purpose. In addition, cells of the immune system used NADPH to kill foreign pathogens through a process called the respiratory burst. A decrease in the ratio of NADPH:NADP+ ratio will compromise the immune system and provide an environment where pathogens can evade killing by phagocytosis. The next reason that the oxidative phase is important is because reducing power is needed for all anabolic processes. This includes the biosynthesis of hormones, so there are high levels of pentose phosphate activity in the adrenal and sex glands. With insufficient reducing power in the form of NADPH, hormonal balance can be thrown out of whack. This includes the adrenal and sex hormones as well as the the thyroid, but for a different reason. Several reversible hormonal conversions are dependent on the ratio of NADPH to NADP+ including: DHEA Androstenediol Androstenedione Testosterone Estrone Estradiol Cortisone Cortisol NADPH causes the conversions to go from left to right while NADP+ causes them to go from right to left. So what does this mean? NADPH will convert androstenedione to testosterone while NADP+ will convert testosterone to androstenedione. In other words, reduced flux through the oxidative arm of the pentose phosphate pathway will negatively impact testosterone levels in men because there will be more NADP+ than NADPH which favors androstenedione over testosterone. I am no expert on women's hormonal issues, but given the fact that estrone is the predominant form of estrogen in postmenopausal women while estradiol is the predominant form in women of reproductive age, I'll go out on a limb and say this conversion is likely detrimental. On the adrenal side of things, reduced flux through the oxidative arm of the pentose phosphate pathway will negatively impact cortisol levels by favoring cortisone production. Since cortisol has greater glucocorticoid activity and cortisone has no mineralocorticoid activity, this can have a pretty significant effect on glucose levels, inflammation, and electrolyte balance. Since these hormonal conversions occur in the endoplasmic reticulum(ER) of cells, the ratio of NADPH:NADP+ within the ER can have a pretty significant effect on hormonal balance. Reduced flux through the pentose phosphate pathway and high levels of oxidative stress are 2 factors that can decrease this ratio leading to poor hormonal balance. With the thyroid, the proposed mechanism by which reduced flux through the oxidative arm of the pentose phosphate pathway may negatively impact hormone production is through a reduction in glutathione function. The thyroid relies on hydrogen peroxide, a free radical, for thyroid hormone synthesis. Without sufficient levels of reduced glutathione to keep this in check, the thyroid can become damaged, inflamed, and thyroid function can become compromised. The non-oxidative phase of the pentose phosphate pathway The non-oxidative arm of the pentose phosphate pathway is also important, especially in tissues with high rates of cell turnover. The non-oxidative arm of the pentose phosphate pathway essentially interconverts sugars in to different forms. One of those sugars, R5P, is necessary for DNA production. Cells with high turnover rates such as epithelial cells in the gut are dependent on sufficient flux through the non-oxidative arm to produce enough DNA for replication. The non-oxidative arm also gives the pentose phosphate pathway flexibility. By interconverting sugars, the non-oxidative arm can create sugars that can re-enter glycolysis to generate pyruvate or feed back in to the oxidative arm to create more NADPH. The non-oxidative arm allows the pentose phosphate pathway and glycolytic pathways to work synergistically to meet cell needs. There are essentially 4 modes of pentose phosphate pathway activity that can be used to increase energy levels, increase reducing power, provide building blocks for DNA, or a combination of these functions. The yield of each mode is: Mode 1-6 G6P makes 5 R5P Mode 2-1 G6P makes 1 R5P and 2 NADPH Mode 3 -1 G6P makes 12 NADPH Mode 4-3 G6P make 6 NADPH, 8 ATP, & 5 pyruvate and NADH which can be used to create more ATP As you can see, carbohydrate metabolism is a lot more than simply breaking down glucose to use for energy. Carbohydrate metabolism also has anabolic effects via the pentose phosphate pathway. Decreased flux through the pentose phosphate pathway can increase oxidative stress and negatively impact hormonal balance and cellular reproduction. There is compelling scientific evidence that altered flux through the pentose phosphate pathway may be at the root of adrenal dysfunction, increased inflammation, and some gut pathologies including SIBO. In addition, many metabolic consequences of Type 2 diabetes can alter flux through the pentose phosphate pathway and there are many blood markers we see in Type 2 diabetes that indicate this. If there is enough demand I may pull some of that stuff out, so read, like, and share.
My main party's dynamic! Part 1: Kaeya's POV (Platonic) - Kaeya-Zhongli: unlike his previous wallets, Kaeya draw the line and stop Zhongli from spending too much. He's trying his best to teach him…
They say time heals everything, and it kind of does, but the scars heartbreak leaves can stay forever. It isn’t only about the pain, it's the constant
This packet targets identifying emotions. It includes print and go worksheets for three levels and an interactive book. In general, 8 emotions are targeted consistently each section: happy, sad, angry, confused, excited, scared, surprised, and tired. Level One There are twenty pages in this section, at least 2 for each emotion. On each worksheet, there is a real picture. The worksheet provides a space to identify how the person feels, and three visual choices so you can circle and color one. Then, on the bottom of the page, have the child identify how they know how the person feels. They should pay attention to the person's mouth, eyes, and body and write relevant clues. See the second preview picture as an example page! Level Two There are seventeen worksheets in this section, 2 for each emotion and one extra because I got carried away :) There is a social scenario on each page. Read it aloud, have the child identify how the person feels, and then draw the emotion on the blank face. Completely black and white! See the third preview picture as an example page! Level Three The last section challenges your students to apply the emotions to themselves/their lives. There is 1 page for each emotion (see above for the list). They should identify when they feel the given emotion, and then draw a picture of a time they felt that way. Completely black and white! See the last preview picture as an example page! Bonus: Interactive Book This interactive book file contains 16 pictures with a simple sentence starter (She feels..., he feels...) on each page. Students should find the icon that matches how the person in the picture feels and attach it to each page below the sentence starter. I like to divide the books into 2 separate books with removable icons attached using Velcro on each book. All pages are black and white except for the level one pages and the interactive book as I utilized real pictures in these sections. Feel free to print in black & white if desired! These pages work great laminated or in lamination pouches so you can reuse them! PLEASE NOTE: This is a zipped file. If you need help opening the file, please click here to read a tutorial from TpT. If you have any questions about this packet, please email me at [email protected] and I'll get back to you as soon as possible. Click on any of the links below to check out my website and social media pages! ♥ I love sharing ideas and connecting with all of you! ❙ SPEECHY MUSINGS BLOG ❙ FACEBOOK ❙ PINTEREST ❙ INSTAGRAM ❙
Если вы куда-то едете или ждете в очереди, в общем, нужно чем-то занять ребенка, подобные истории очень выручают. Их смысл в том, что вы рисуете и одновременно рассказываете сказку. Когда рисунок закончен, получается изображение, которое изначально не ожидалось. В общем, проще показать, чем объяснять))) В этом посте я собрала несколько штук.
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One of the few conversations he has had with his father before he is sent away. Kronos has already been defeated and is chilling at a cave for the time being while everything is being sorted out.
Jackie Morris is a British writer and illustrator. She was shortlisted for the Kate Greenaway Medal in 2016 and won it in 2019 for her illustration of
